Effects of immunosuppressive therapy on wound healing

被引：108

作者：

Bootun, Roshan ^{[1
]}

机构：

[1] Cardiff Univ, Dept Wound Healing & Tissue Repair, Cardiff CF10 3AX, S Glam, Wales

来源：

INTERNATIONAL WOUND JOURNAL | 2013年 / 10卷 / 01期

关键词：

Immunosuppressive agents; Wound healing; MYCOPHENOLATE-MOFETIL IMPAIRS; KIDNEY-TRANSPLANTATION; SURGICAL COMPLICATIONS; MOLECULAR-MECHANISMS; CYCLOSPORINE-A; SIROLIMUS; RAPAMYCIN; AZATHIOPRINE; TACROLIMUS; EVEROLIMUS;

D O I：

10.1111/j.1742-481X.2012.00950.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Immunosuppressive therapy is increasingly being used in clinical practice and has been shown to affect wound healing to varying degrees. This article looks at the effects of the newer immunosuppressive agents on wound healing. It is shown that wound healing is impaired via different mechanisms. Some of the animal and human studies are reviewed in more detail. It is shown that some of the newer agents affect wound healing to such an extent that reduction or avoidance of these drugs until complete wound healing is achieved is advocated. More research is required for these newer agents to determine the most appropriate time to introduce them.

引用

页码：98 / 104

页数：7

共 33 条

[1]

Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study [J].

Al Rifai, Ahmad ;

Prasad, Neeraj ;

Shuttleworth, Elinor ;

McBurney, Helen ;

Pushpakom, Sudeep ;

Robinson, Andrew ;

Newman, William ;

Campbell, Simon .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2011, 23 (02) :153-158

[2]

Incidence of Delayed Graft Function and Wound Healing Complications After Deceased-Donor Kidney Transplantation Is not Affected by De Novo Everolimus [J].

Albano, Laetitia ;

Berthoux, Francois ;

Moal, Marie-Christine ;

Rostaing, Lionel ;

Legendre, Christophe ;

Genin, Robert ;

Toupance, Olivier ;

Moulin, Bruno ;

Merville, Pierre ;

Rerolle, Jean-Philippe ;

Bayle, Francois ;

Westeel, Pierre Francois ;

Glotz, Denis ;

Kossari, Niloufar ;

Lefrancois, Nicole ;

Charpentier, Bernard ;

Blanc, Anne-Sandrine ;

Di Giambattista, Fabienne ;

Dantal, Jacques .

TRANSPLANTATION, 2009, 88 (01) :69-76

[3]

Baum CL, 2005, DERMATOL SURG, V31, P674

[4]

CYCLOSPORINE-A AND FK506 - MOLECULAR MECHANISMS OF IMMUNOSUPPRESSION AND PROBES FOR TRANSPLANTATION BIOLOGY [J].

BIERER, BE ;

HOLLANDER, G ;

FRUMAN, D ;

BURAKOFF, SJ .

CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (05) :763-773

[5]

The effects of sirolimus on wound healing in dermatologic surgery [J].

Brewer, Jerry D. ;

Otley, Clark C. ;

Christenson, Leslie J. ;

Phillips, P. Kim ;

Roenigk, Randall K. ;

Weaver, Amy L. .

DERMATOLOGIC SURGERY, 2008, 34 (02) :216-223

[6]

The basic science of wound healing [J].

Broughton, George, II ;

Janis, Jeffrey E. ;

Attinger, Christopher E. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 117 (07) :12S-34S

[7]

Post-kidney transplant surgical complications under new immunosuppressive regimens [J].

Burgos, F. J. ;

Pascual, J. ;

Quicios, C. ;

Marcen, R. ;

Fernandez, A. ;

Fando, L. Lopez ;

Ortuno, J. .

TRANSPLANTATION PROCEEDINGS, 2006, 38 (08) :2445-2447

[8]

Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation [J].

Campistol, Josep M. ;

Cockwell, Paul ;

Diekmann, Fritz ;

Donati, Donato ;

Guirado, Luis ;

Herlenius, Gustaf ;

Mousa, Dujanah ;

Pratschke, Johann ;

San Millan, Juan Carlos Ruiz .

TRANSPLANT INTERNATIONAL, 2009, 22 (07) :681-687

[9]

Wound-healing complications after kidney transplantation: A prospective, randomized comparison of sirolimus and tacrolimus [J].

Dean, PG ;

Lund, WJ ;

Larson, TS ;

Prieto, M ;

Nyberg, SL ;

Ishitani, MB ;

Kremers, WK ;

Stegall, MD .

TRANSPLANTATION, 2004, 77 (10) :1555-1561

[10]

Effect of rapamycin on wound healing: An experimental study [J].

Ekici, Y. ;

Emiroglu, R. ;

Ozdemir, H. ;

Aldemir, D. ;

Karakayali, H. ;

Haberal, M. .

TRANSPLANTATION PROCEEDINGS, 2007, 39 (04) :1201-1203

← 1 2 3 4 →