Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis

被引：410

作者：

Henry, Brandon Michael ^{[1
]}

Aggarwal, Gaurav ^{[2
]}

Wong, Johnny ^{[3
]}

Benoit, Stefanie ^{[4
,5
]}

Vikse, Jens ^{[6
]}

Plebani, Mario ^{[7
]}

Lippi, Giuseppe ^{[8
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Heart Inst, Cardiac Intens Care Unit, 3333 Bumet Ave, Cincinnati, OH 45229 USA

[2] Jersey City Med Ctr, Dept Med, Jersey City, NJ USA

[3] SUNY Downstate Hlth Sci Univ, Coll Med, New York, NY USA

[4] Cincinnati Childrens Hosp Med Ctr, Div Nephrol & Hypertens, Cincinnati, OH 45229 USA

[5] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45221 USA

[6] Stavanger Univ Hosp, Dept Clin Immunol, Stavanger, Norway

[7] Univ Hosp, Dept Lab Med, Padua, Italy

[8] Univ Verona, Dept Neurosci Biomed & Movement, Sect Clin Biochem, Verona, Italy

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 2020年 / 38卷 / 09期

关键词：

Lactate dehydrogenase; COVID-19; Coronavirus; CLINICAL CHARACTERISTICS;

D O I：

10.1016/j.ajem.2020.05.073

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in patients with viral infections. In this pooled analysis of 9 published studies (n= 1532 COVID-19 patients), we evaluated the association between elevated LDH levels measured at earliest time point in hospitalization and disease outcomes in patients with COVID-19. Elevated LDH levels were associated with a similar to 6-fold increase in odds of developing severe disease and a similar to 16-fold increase in odds of mortality in patients with COVID-19. Larger studies are needed to confirm these findings. (c) 2020 Elsevier Inc. All rights reserved.

引用

页码：1722 / 1726

页数：5

共 25 条

[1]

[Anonymous], COR DIS 2019 COVID 1

[2]

[Anonymous], 2020, MEDRXIV

[3]

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Al-Rabeeah, Abdullah A. ;

Al-Rabiah, Fahad A. ;

Al-Hajjar, Sami ;

Al-Barrak, Ali ;

Flemban, Hesham ;

Al-Nassir, Wafa N. ;

Balkhy, Hanan H. ;

Al-Hakeem, Rafat F. ;

Makhdoom, Hatem Q. ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761

[4]

Chen Cheng-Yu, 2005, J Chin Med Assoc, V68, P4, DOI 10.1016/S1726-4901(09)70124-8

[5]

Eight-month prospective study of 14 patients with hospital-acquired severe acute respiratory syndrome [J].

Chiang, CH ;

Shih, JF ;

Su, WJ ;

Perng, RP .

MAYO CLINIC PROCEEDINGS, 2004, 79 (11) :1372-1379

[6]

Erez A, 2014, ISR MED ASSOC J, V16, P439

[7]

Clinical Characteristics of Coronavirus Disease 2019 in China [J].

Guan, W. ;

Ni, Z. ;

Hu, Yu ;

Liang, W. ;

Ou, C. ;

He, J. ;

Liu, L. ;

Shan, H. ;

Lei, C. ;

Hui, D. S. C. ;

Du, B. ;

Li, L. ;

Zeng, G. ;

Yuen, K. -Y. ;

Chen, R. ;

Tang, C. ;

Wang, T. ;

Chen, P. ;

Xiang, J. ;

Li, S. ;

Wang, Jin-lin ;

Liang, Z. ;

Peng, Y. ;

Wei, L. ;

Liu, Y. ;

Hu, Ya-hua ;

Peng, P. ;

Wang, Jian-ming ;

Liu, J. ;

Chen, Z. ;

Li, G. ;

Zheng, Z. ;

Qiu, S. ;

Luo, J. ;

Ye, C. ;

Zhu, S. ;

Zhong, N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) :1708-1720

[8]

Henry B.M., 2020, CLIN CHEM LAB MED

[9]

Estimating the mean and variance from the median, range, and the size of a sample [J].

Hozo S.P. ;

Djulbegovic B. ;

Hozo I. .

BMC Medical Research Methodology, 5 (1)

[10]

Cancer cell metabolism: Warburg and beyond [J].

Hsu, Peggy P. ;

Sabatini, David M. .

CELL, 2008, 134 (05) :703-707

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