Synthesis and Structure Revision of Nakiterpiosin

被引：108

作者：

Gao, Shuanhu ^{[1
]}

Wang, Oiaoling ^{[1
]}

Chen, Chuo ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 04期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; PHOTO-NAZAROV CYCLIZATION; NOR-D-HOMOSTEROIDS; AROMATIC KETONES; ALDOL REACTION; REARRANGEMENT; VERATRAMINE; ALDEHYDES; ORGANOSTANNANES; CYCLOPAMINE;

D O I：

10.1021/ja808110d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This manuscript describes a convergent synthesis and the revision of the relative stereochemistry of nakiterpiosin, a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently.

引用

页码：1410 / +

页数：4

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