Monomer networking activates recombinases

被引：4

作者：

Wyman, C

机构：

[1] Erasmus Univ, Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands

来源：

STRUCTURE | 2006年 / 14卷 / 06期

关键词：

D O I：

10.1016/j.str.2006.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recombinases catalyze the DNA strand-exchange reactions of homologous recombination. The regularity of the filaments they form on DNA, though beautiful, does not explain how they work. Functionally important internal interactions now include multiple intermonomer contacts for activation (Galkin et al., 2006).

引用

收藏

页码：949 / 950

页数：2

相关论文

共 8 条

[1] Crystal structure of a Rad51 filament [J].

Conway, AB ;

Lynch, TW ;

Zhang, Y ;

Fortin, GS ;

Fung, CW ;

Symington, LS ;

Rice, PA .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (08) :791-796

[2] Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function [J].

Ristic, D ;

Modesti, M ;

van der Heijden, T ;

van Noort, J ;

Dekker, C ;

Kanaar, R ;

Wyman, C .

NUCLEIC ACIDS RESEARCH, 2005, 33 (10) :3292-3302

[3] THE STRUCTURE OF THE ESCHERICHIA-COLI RECA PROTEIN MONOMER AND POLYMER [J].

STORY, RM ;

WEBER, IT ;

STEITZ, TA .

NATURE, 1992, 355 (6358) :318-325

[4] ATP-Mediated conformational changes in the RecA filament [J].

VanLoock, MS ;

Yu, X ;

Yang, SX ;

Lai, AL ;

Low, C ;

Campbell, MJ ;

Egelman, EH .

STRUCTURE, 2003, 11 (02) :187-196

[5] Crystal structure of archaeal recombinase RadA: A snapshot of its extended conformation [J].

Wu, Y ;

He, Y ;

Moya, IA ;

Qian, XG ;

Luo, Y .

MOLECULAR CELL, 2004, 15 (03) :423-435

[6] Homologous recombination: Down to the wire [J].

Wyman, C ;

Kanaar, R .

CURRENT BIOLOGY, 2004, 14 (15) :R629-R631

[7] What is the structure of the RecA-DNA filament? [J].

Yu, X ;

VanLoock, MS ;

Yang, S ;

Reese, JT ;

Egelman, EH .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2004, 5 (02) :73-79

[8] Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA [J].

Yu, X ;

Jacobs, SA ;

West, SC ;

Ogawa, T ;

Egelman, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8419-8424