Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats

被引：42

作者：

Li, Pei-Bo ^{[1
]}

Lin, Wan-Ling ^{[1
]}

Wang, Yong-Gang ^{[1
]}

Peng, Wei ^{[1
]}

Cai, Xue-Ying ^{[1
]}

Su, Wei-Wei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Key Lab Gene Engn, Minist Educ, Guangdong Key Lab Plant Resources,Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Oligosaccharides of Ophiopogonis japonicus; Antidiabetic effect; Type 2 diabetes mellitus; GLYCOGEN-SYNTHASE ACTIVITY; INSULIN-RESISTANCE; PLASMA-GLUCOSE; DIET; GLUCAGON; POLYSACCHARIDE; STREPTOZOTOCIN; MAINTENANCE; PROTEINURIA; EXPRESSION;

D O I：

10.1016/j.ijbiomac.2012.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present study is to investigate the antidiabetic properties of oligosaccharides of Ophiopogonis japonicus (OOJ) in experimental type 2 diabetic rats. OOJ was administered orally in doses of 225 and 450 mg/kg body weight to high-fat diet and low-dose streptozotocin (STZ)-induced type 2 diabetic rats for 3 weeks. The results showed that OOJ treatment could increase body weight, decrease organ related weights of liver and kidney, reduce fasting blood glucose level, and improve oral glucose tolerance in diabetic rats. Moreover, increased glycogen content in liver and skeletal muscle, reduced urinary protein excretion, higher hepatic GCK enzyme activity, lower hepatic PEPCK enzyme activity, enhanced GLP-1 level, decreased glucagon level and alleviated histopathological changes of pancreas occurred in OOJ-treated diabetic rats by comparison with untreated diabetic rats. This study demonstrates, for the first time to our knowledge, that OOJ exerts remarkable antidiabetic effect in experimental type 2 diabetes mellitus, thus justifying its traditional usage. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：749 / 755

页数：7

共 43 条

[1] Diagnosis and Classification of Diabetes Mellitus
[J]. DIABETES CARE, 2010, 33 : S62 - S69
[2] Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy
Atkins, RC
Briganti, EM
Lewis, JB
Hunsicker, LG
Braden, G
de Crespigny, PJC
DeFerrari, G
Drury, P
Locatelli, F
Wiegmann, TB
Lewis, EJ
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 45 (02) : 281 - 287
[3] Babu PS, 2007, PHYTOMEDICINE, V14, P15, DOI 10.1016/j.phymed.2006.11.005
[4] ROLE OF HYPERGLUCAGONEMIA IN MAINTENANCE OF INCREASED RATES OF HEPATIC GLUCOSE OUTPUT IN TYPE-II DIABETICS
BARON, AD
SCHAEFFER, L
SHRAGG, P
KOLTERMAN, OG
[J]. DIABETES, 1987, 36 (03) : 274 - 283
[5] Centers for Disease Control and Prevention (CDC), 2004, MMWR Morb Mortal Wkly Rep, V53, P1066
[6] Role of JNK activation in pancreatic β-cell death by streptozotocin
Cheon, Hwanju
Cho, Jae Min
Kim, Sunshin
Baek, Seung-Hoon
Lee, Moon-Kyu
Kim, Kwang-Won
Yu, Seong-Woon
Solinas, Giovanni
Kim, Soung Soo
Lee, Myung-Shik
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 321 (02) : 131 - 137
[7] Plasma homocysteine concentrations in type II diabetic patients in India: Relationship to body weight
Das, S
Reynolds, T
Patnaik, A
Rais, N
Fink, LM
Fonseca, VA
[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 1999, 13 (04) : 200 - 203
[8] THE PHOSPHORYLATION STATE OF THE CAMP RESPONSE ELEMENT-BINDING PROTEIN IS DECREASED IN DIABETIC RAT-LIVER
DAVIES, GF
CROSSON, SM
KHANDELWAL, RL
ROESLER, WJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 323 (02) : 477 - 483
[9] Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone:: a peroxisome proliferator-activated receptor-γ (PPARγ)-independent, antioxidant-related mechanism
Davies, GF
Khandelwal, RL
Wu, LY
Juurlink, BHJ
Roesler, WJ
[J]. BIOCHEMICAL PHARMACOLOGY, 2001, 62 (08) : 1071 - 1079
[10] Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL
de Zeeuw, D
Remuzzi, G
Parving, HH
Keane, WF
Zhang, ZX
Shahinfar, S
Snapinn, S
Cooper, MF
Mitch, WE
Brenner, BM
[J]. KIDNEY INTERNATIONAL, 2004, 65 (06) : 2309 - 2320

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