Fluorodeoxyglucose positron emission tomography of soft tissue tumours: is a non-invasive determination of biological activity possible?

被引:75
作者
Schulte, M
Brecht-Krauss, D
Heymer, B
Guhlmann, A
Hartwig, E
Sarkar, MR
Diederichs, CG
Schultheiss, M
Kotzerke, J
Reske, SN
机构
[1] Univ Hosp Ulm, Dept Trauma Hand & Reconstruct Surg, Ulm, Germany
[2] Univ Hosp Ulm, Dept Nucl Med, Ulm, Germany
[3] Univ Hosp Ulm, Dept Pathol, Ulm, Germany
关键词
soft tissue neoplasms; sarcoma; fluorode-oxyglucose;
D O I
10.1007/s002590050427
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Since musculoskeletal tumours comprise a large heterogeneous group of entities with different biological behaviour, clinical diagnosis of such lesions can be very difficult. The aim of this prospective study was to assess the usefulness of 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the non-invasive evaluation of soft tissue tumours. One hundred and two patients with suspected soft tissue neoplasms were investigated by FDG-PET. The uptake of FDG was evaluated semiquantitatively by determining the tumour to background ratio (TBR). All patients underwent biopsy, resulting in the histological detection of 39 high-grade sarcomas, 16 intermediate-grade sarcomas, 11 low-grade sarcomas, 25 benign tumours, 10 tumour-like lesions such as spontaneous myositis ossificans (n = 6) and one non-Hodgkin lymphoma. All lesions except for two lipomas disclosed an increased FDG uptake. Sarcomas showed significantly higher TBR values than latent or active benign lesions (P<0.001) and aggressive benign lesions (P<0.05). Using a TBR cut -off level of 3.0 for malignancy, sensitivity of FDC-PET was 97.0%, specificity 65.7% and accuracy 86.3%. From our data there are three main conclusions: (1) Except for patients with pseudotumoral myositis ossificans, lesions with a TBR >3 were sarcomas (91.7%) or aggressive benign tumours (8.3%). (2) Tumours with a TBR <1.5 were latent or active benign lesions, exclusively. (3) The group with intermediate TBR values (<3 and >1.5) comprised primarily latent or active benign lesions, but also four aggressive benign tumours and two low-grade sarcomas. Our data suggest that FDG-PET represents a useful tool for the evaluation of the biological activity of soft tissue neoplasms.
引用
收藏
页码:599 / 605
页数:7
相关论文
共 27 条
[1]  
ADLER LP, 1991, J NUCL MED, V32, P1508
[2]   GRADING LIPOSARCOMAS WITH PET USING [F-18] FDG [J].
ADLER, LP ;
BLAIR, HF ;
WILLIAMS, RP ;
PATHRIA, MN ;
MAKLEY, JT ;
JOYCE, MJ ;
ALKAISI, N ;
MIRALDI, F .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1990, 14 (06) :960-962
[3]  
[Anonymous], 1939, SURG GYNAECOL OBSTET
[4]   MR-IMAGING OF SOFT-TISSUE MASSES - ROLE OF GADOPENTETATE DIMEGLUMINE [J].
BENEDIKT, RA ;
JELINEK, JS ;
KRANSDORF, MJ ;
MOSER, RP ;
BERREY, BH .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (03) :485-490
[5]   SOFT-TISSUE SARCOMA - MR IMAGING VS SONOGRAPHY FOR DETECTION OF LOCAL RECURRENCE AFTER SURGERY [J].
CHOI, H ;
VARMA, DGK ;
FORNAGE, BD ;
KIM, EE ;
JOHNSTON, DA .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1991, 157 (02) :353-358
[6]  
COINDRE JM, 1986, CANCER, V58, P306, DOI 10.1002/1097-0142(19860715)58:2<306::AID-CNCR2820580216>3.0.CO
[7]  
2-7
[8]   DIAGNOSIS OF SOFT-TISSUE MASSES WITH MR IMAGING - CAN BENIGN MASSES BE DIFFERENTIATED FROM MALIGNANT ONES [J].
CRIM, JR ;
SEEGER, LL ;
YAO, L ;
CHANDANI, V ;
ECKARDT, JJ .
RADIOLOGY, 1992, 185 (02) :581-586
[9]  
Eary JF, 1998, CLIN CANCER RES, V4, P1215
[10]  
ENNEKING WF, 1986, CLIN ORTHOP RELAT R, P9