Four genes encoding different type I signal peptidases are organized in a cluster in Streptomyces lividans TK21

被引：35

作者：

Parro, V

Schacht, S

Anné, J

Mellado, RP

机构：

[1] CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

[2] Katholieke Univ Leuven, Rega Inst, Bacteriol Lab, B-3000 Louvain, Belgium

来源：

MICROBIOLOGY-SGM | 1999年 / 145卷

关键词：

signal peptidases; secretion; Streptomyces;

D O I：

10.1099/00221287-145-9-2255

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Four adjacent genes (sipW, sipX, sipY and sipZ) encoding different type I signal peptidases, were isolated on a 7860 bp DNA fragment from Streptomyces lividans TK21. Three of the sip genes constitute an operon and the fourth is the first gene of another operon encompassing three additional, unrelated genes. A DNA fragment containing the four sip genes complemented an Escherichia coli type I signal peptidase mutant when cloned in a multicopy plasmid. Clustering of four different type I signal peptidase genes seems, so far, to be a unique feature of Streptomyces.

引用

收藏

页码：2255 / 2263

页数：9

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