Absolute stereostructures of new arborinane-type triterpenoids and inhibitors of nitric oxide production from Rubia yunnanensis

被引：40

作者：

Morikawa, T ^{[1
]}

Tao, J ^{[1
]}

Ando, S ^{[1
]}

Matsuda, H ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 05期

关键词：

D O I：

10.1021/np0205710

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aqueous acetone extract from the roots of a Chinese herbal medicine, Rubia yunnanensis, showed a potent inhibitory effect on nitric oxide production in lipopolysaccharide-activated macrophages. Five new arborinane-type triterpenes, rubianols-a (1), -b (2), -c (3), -d (4), and -e (5), and a new arborinane-type triterpene glycoside, rubianoside I (6), were isolated from the herbal crude extract together with 10 known compounds. The absolute stereostructures of 1-6 were determined on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method. The effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined, and several triterpenes were found to show inhibitory activity.

引用

页码：638 / 645

页数：8

共 15 条

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