Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults

被引：49

作者：

Lee, JH

Shin, JH

Roe, IH

Sohn, SG

Lee, JH

Kang, GH

Lee, HK

Jeong, BC

Lee, SH

机构：

[1] Myongji Univ, Dept Biol Sci, Kyunggido 449728, South Korea

[2] Dankook Univ, Coll Med, Res Ctr Gastroenterol, Cheonan, Choongnamdo, South Korea

[3] Dankook Univ, Coll Med, Dept Gastroenterol, Cheonan, Choongnamdo, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1600-1603.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The outcome of Helicobacter pylori infection was analyzed in 114 dyspeptic patients treated with triple-drug therapy including clarithromycin. Clarithromycin resistance (in 20.2% of our isolates) was mainly caused by an A2142G mutation in the 23S rRNA gene of H. pylori. H. pylori eradication was obtained in all patients with clarithromycin-susceptible isolates but not in any patients with clarithromycin-resistant isolates (P = 0.0001). Therefore, it would be useful to conduct H. pylori antimicrobial susceptibility testing of the first gastric biopsy culture before choosing the first three drugs for therapy of infected patients.

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页码：1600 / 1603

页数：4

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