Motilin increases food intake in mice

被引：39

作者：

Asakawa, A

Inui, A

Momose, K

Ueno, N

Fujino, MA

Kasuga, M

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 650, Japan

[2] Yamanashi Med Univ, Dept Internal Med 1, Yamanashi 40938, Japan

来源：

PEPTIDES | 1998年 / 19卷 / 06期

关键词：

motilin; ICV; feeding; GM-109; brain;

D O I：

10.1016/S0196-9781(97)00477-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of motilin on food intake was investigated in nonfood-deprived mice. A significant increase in food intake was observed 1 h after ICV administration of motilin (3 nmol/mouse) and continued for 2 h. This effect was attenuated markedly by the motilin receptor antagonist GM-109 (0.3-3 nmol/mouse) in a dose-related manner. GM-109 alone had no effect on food intake. These results indicate that motilin receptors are present in the brain and may have a role in the regulation of food intake. (C) 1998 Elsevier Science Inc.

引用

页码：987 / 990

页数：4

共 30 条

[21] MOTILIN EXCITES NEURONS IN THE CEREBRAL-CORTEX AND SPINAL-CORD [J].