Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo:: Results from the EUROFORS study

被引：123

作者：

Graeff, Christian

Timm, Wolfram

Nickelsen, Thomas N.

Farrerons, Jordi

Marin, Fernando

Barker, Clare

Glueer, Claus C.

机构：

[1] Univ Klinikum Schleswig Holstein, Radiol Diagnost Klin, Lubeck, Germany

[2] Eli Lilly & Co, Windlesham, Surrey, England

[3] Hosp Santa Creu & Sant Pau, E-08025 Barcelona, Spain

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 09期

关键词：

osteoporosis; teriparatide; bone microstructure; CT; BMD;

D O I：

10.1359/jbmr.070603

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We introduce a method for microstructural analysis of vertebral trabecular bone in vivo based on HRCT. When applied to monitor teriparatide treatment, changes in structural variables exceeded and were partially independent of changes in volumetric BMD.

引用

收藏

页码：1426 / 1433

页数：8

相关论文

共 27 条

[1] Architecture and distribution of cancellous bone yield vertebral fracture clues - A histomorphometric analysis of the complete spinal column from 40 autopsy specimens [J].

Amling, M ;

Posl, M ;

Ritzel, H ;

Hahn, M ;

Vogel, M ;

Wening, VJ ;

Delling, G .

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 1996, 115 (05) :262-269

[2] SEX-DIFFERENCES IN GEOMETRY OF THE FEMORAL-NECK WITH AGING - A STRUCTURAL-ANALYSIS OF BONE-MINERAL DATA [J].

BECK, TJ ;

RUFF, CB ;

SCOTT, WW ;

PLATO, CC ;

TOBIN, JD ;

QUAN, CA .

CALCIFIED TISSUE INTERNATIONAL, 1992, 50 (01) :24-29

[3] In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography [J].

Boutroy, S ;

Bouxsein, ML ;

Munoz, F ;

Delmas, PD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6508-6515

[4] CT IMAGE-ANALYSIS OF THE VERTEBRAL TRABECULAR NETWORK INVIVO [J].

CHEVALIER, F ;

LAVALJEANTET, AM ;

LAVALJEANTET, M ;

BERGOT, C .

CALCIFIED TISSUE INTERNATIONAL, 1992, 51 (01) :8-13

[5] Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs [J].

Cummings, SR ;

Karpf, DB ;

Harris, F ;

Genant, HK ;

Ensrud, K ;

LaCroix, AZ ;

Black, DM .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (04) :281-289

[6] Monitoring skeletal changes by radiological techniques [J].

Glüer, CC .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (11) :1952-1962

[7]

GLUER CC, 1994, J BONE MINER RES, V9, P671

[8]

IGLEWICZ N, 1993, DETECT HANDLE OUTLIE, V16

[9] Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk [J].

Ito, M ;

Ikeda, K ;

Nishiguchi, M ;

Shindo, H ;

Uetani, M ;

Hosoi, T ;

Orimo, H .

JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (10) :1828-1836

[10] TRABECULAR TEXTURE ANALYSIS OF CT IMAGES IN THE RELATIONSHIP WITH SPINAL FRACTURE [J].

ITO, M ;

OHKI, M ;

HAYASHI, K ;

YAMADA, M ;

UETANI, M ;

NAKAMURA, T .

RADIOLOGY, 1995, 194 (01) :55-59