Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo:: Results from the EUROFORS study

被引:123
作者
Graeff, Christian
Timm, Wolfram
Nickelsen, Thomas N.
Farrerons, Jordi
Marin, Fernando
Barker, Clare
Glueer, Claus C.
机构
[1] Univ Klinikum Schleswig Holstein, Radiol Diagnost Klin, Lubeck, Germany
[2] Eli Lilly & Co, Windlesham, Surrey, England
[3] Hosp Santa Creu & Sant Pau, E-08025 Barcelona, Spain
关键词
osteoporosis; teriparatide; bone microstructure; CT; BMD;
D O I
10.1359/jbmr.070603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We introduce a method for microstructural analysis of vertebral trabecular bone in vivo based on HRCT. When applied to monitor teriparatide treatment, changes in structural variables exceeded and were partially independent of changes in volumetric BMD.
引用
收藏
页码:1426 / 1433
页数:8
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