Wnt signalling in stem cells and cancer

被引：2906

作者：

Reya, T ^{[1
]}

Clevers, H

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

NATURE | 2005年 / 434卷 / 7035期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature03319

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.

引用

页码：843 / 850

页数：8

共 91 条

[1] A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
Austin, TW
Solar, GP
Ziegler, FC
Liem, L
Matthews, W
[J]. BLOOD, 1997, 89 (10) : 3624 - 3635
[2] AXIN1 mutations but not deletions in cerebellar medulloblastomas
Baeza, N
Masuoka, J
Kleihues, P
Ohgaki, H
[J]. ONCOGENE, 2003, 22 (04) : 632 - 636
[3] β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB
Batlle, E
Henderson, JT
Beghtel, H
van den Born, MMW
Sancho, E
Huls, G
Meeldijk, J
Robertson, J
van de Wetering, M
Pawson, T
Clevers, H
[J]. CELL, 2002, 111 (02) : 251 - 263
[4] CYTOLOGICAL DEMONSTRATION OF CLONAL NATURE OF SPLEEN COLONIES DERIVED FROM TRANSPLANTED MOUSE MARROW CELLS
BECKER, AJ
TILL, JE
MCCULLOCH, EA
[J]. NATURE, 1963, 197 (486) : 452 - &
[5] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
Bhardwaj, G
Murdoch, B
Wu, D
Baker, DP
Williams, KP
Chadwick, K
Ling, LE
Karanu, FN
Bhatia, M
[J]. NATURE IMMUNOLOGY, 2001, 2 (02) : 172 - 180
[6] Clonal analysis of mouse intestinal epithelial progenitors
Bjerknes, M
Cheng, H
[J]. GASTROENTEROLOGY, 1999, 116 (01) : 7 - 14
[7] Gut instincts: thoughts on intestinal epithelial stem cells
Booth, C
Potten, CS
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (11) : 1493 - 1499
[8] WNT signaling modulates the diversification of hematopoietic cells
Brandon, C
Eisenberg, LM
Eisenberg, CA
[J]. BLOOD, 2000, 96 (13) : 4132 - 4141
[9] Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis
Braun, KM
Niemann, C
Jensen, UB
Sundberg, JP
Silva-Vargas, V
Watt, FM
[J]. DEVELOPMENT, 2003, 130 (21): : 5241 - 5255
[10] Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, LM
Adams, GB
Weibrecht, KW
Weber, JM
Olson, DP
Knight, MC
Martin, RP
Schipani, E
Divieti, P
Bringhurst, FR
Milner, LA
Kronenberg, HM
Scadden, DT
[J]. NATURE, 2003, 425 (6960) : 841 - 846

← 1 2 3 4 5 6 7 8 9 10 →