Wnt signalling in stem cells and cancer

被引：2906

作者：

Reya, T ^{[1
]}

Clevers, H

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

NATURE | 2005年 / 434卷 / 7035期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature03319

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.

引用

页码：843 / 850

页数：8

共 91 条

[81] Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
Watkins, DN
Berman, DM
Burkholder, SG
Wang, BL
Beachy, PA
Baylin, SB
[J]. NATURE, 2003, 422 (6929) : 313 - 317
[82] Translating stem and progenitor cell biology to the clinic: Barriers and opportunities
Weissman, IL
[J]. SCIENCE, 2000, 287 (5457) : 1442 - 1446
[83] Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K
Brown, JD
Danenberg, E
Duncan, AW
Weissman, IL
Reya, T
Yates, JR
Nusse, R
[J]. NATURE, 2003, 423 (6938) : 448 - 452
[84] Deletion of β-catenin impairs T cell development
Xu, YY
Banerjee, D
Huelsken, J
Birchmeier, W
Sen, JM
[J]. NATURE IMMUNOLOGY, 2003, 4 (12) : 1177 - 1182
[85] Wnt signaling regulates hemopoiesis through stromal cells
Yamane, T
Kunisada, T
Tsukamoto, H
Yamazaki, H
Niwa, H
Takada, S
Hayashi, SI
[J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (02) : 765 - 772
[86] β-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Zechner, D
Fujita, Y
Hülsken, J
Müller, T
Walther, I
Taketo, MM
Crenshaw, EB
Birchmeier, W
Birchmeier, C
[J]. DEVELOPMENTAL BIOLOGY, 2003, 258 (02) : 406 - 418
[87] Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, JW
Niu, C
Ye, L
Huang, HY
He, X
Tong, WG
Ross, J
Haug, J
Johnson, T
Feng, JQ
Harris, S
Wiedemann, LM
Mishina, Y
Li, LH
[J]. NATURE, 2003, 425 (6960) : 836 - 841
[88] γ-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells
Zheng, XM
Beissert, T
Kukoc-Zivojnov, N
Puccetti, E
Altschmied, J
Strolz, C
Boehrer, S
Gul, H
Schneider, O
Ottmann, OG
Hoelzer, D
Henschler, R
Ruthardt, M
[J]. BLOOD, 2004, 103 (09) : 3535 - 3543
[89] LYMPHOID ENHANCER FACTOR-1 DIRECTS HAIR FOLLICLE PATTERNING AND EPITHELIAL-CELL FATE
ZHOU, PB
BYRNE, C
JACOBS, J
FUCHS, E
[J]. GENES & DEVELOPMENT, 1995, 9 (06) : 700 - 713
[90] Zhu AJ, 1999, DEVELOPMENT, V126, P2285

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