Deletion of β-catenin impairs T cell development

被引：147

作者：

Xu, YY

Banerjee, D

Huelsken, J

Birchmeier, W

Sen, JM

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Brandeis Univ, Rosenstiel Ctr Biomed Res, Waltham, MA 02540 USA

[3] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ni1008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the TCR. Here we show that T cell-specific deletion of beta-catenin impaired T cell development at the beta-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development.

引用

收藏

页码：1177 / 1182

页数：6

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