Oral Treatment for Mycobacterium ulcerans Infection: Results From a Pilot Study in Benin

被引：67

作者：

Chauty, Annick ^{[3
,4
]}

Ardant, Marie-Francoise ^{[3
]}

Marsollier, Laurent ^{[1
,2
]}

Pluschke, Gerd ^{[7
,8
]}

Landier, Jordi ^{[5
]}

Adeye, Ambroise ^{[3
]}

Goundote, Aime ^{[3
]}

Cottin, Jane ^{[2
]}

Ladikpo, Titilola ^{[3
]}

Ruf, Therese ^{[7
,8
]}

Ji, Baohong ^{[6
]}

机构：

[1] CHU Angers, Grp Etud Interact Hote Pathogene, F-49033 Angers 01, France

[2] Univ Angers, Grp Etud Interact Hote Pathogene, Angers, France

[3] Ctr Diagnost & Traitement Ulcere Buruli, Benin, Nigeria

[4] Fdn Raoul Follereau, Paris, France

[5] Inst Pasteur, Unite Epidemiol Malad Emergentes, Paris, France

[6] Univ Paris 06, Fac Med, Paris, France

[7] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[8] Univ Basel, Basel, Switzerland

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 52卷 / 01期

关键词：

ADMINISTERED COMBINED REGIMENS; BURULI ULCER; STREPTOMYCIN; COMBINATION; EFFICACY;

D O I：

10.1093/cid/ciq072

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. The treatment was well tolerated, and all patients were healed by 12 months after initiation of therapy without relapse.

引用

页码：94 / 96

页数：3

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