Interpreting and reporting clinical trials with results of borderline significance

被引：72

作者：

Hackshaw, Allan ^{[1
]}

Kirkwood, Amy ^{[1
]}

机构：

[1] UCL, Canc Res UK & UCL Canc Trials Ctr, London W1T 4TJ, England

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2011年 / 343卷

关键词：

PHASE-III; RANDOMIZED-TRIAL; INTERVENTION; CANCER; CHEMOTHERAPY; THERAPY; ABSENCE;

D O I：

10.1136/bmj.d3340

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The quality of randomised clinical trials and how they are reported have improved over time, with clearer guidelines on conduct and statistical analysis.(1) Clinical trials often take several years, but interpreting the results at the end is arguably the most important activity because it influences whether a new intervention is recommended or not. Although researchers have become more familiar with medical statistics, the interpretation and reporting of results of borderline significance remains a problem. We examine the problem and recommend some solutions.

引用

页数：5

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