Improved passive oral drug delivery via prodrugs

被引：49

作者：

Taylor, MD

机构：

[1] Parke-Davis Pharmaceutical Res. Div., Warner-Lambert Company, Ann Arbor, MI 48105

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1996年 / 19卷 / 02期

关键词：

prodrug; passive absorption; oral absorption;

D O I：

10.1016/0169-409X(95)00104-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Employing prodrugs to improve drug delivery and oral absorption, in particular, is a proven strategy. This review describes recent examples of prodrugs intended to improve oral delivery through enhanced passive transcellular absorption. The underlying biophysics of passive transcellur transport also is discussed as a framework for prodrug design.

引用

收藏

页码：131 / 148

页数：18

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