Embryonic Heart Progenitors and Cardiogenesis

被引：164

作者：

Brade, Thomas ^{[1
]}

Pane, Luna S. ^{[1
]}

Moretti, Alessandra ^{[1
,2
]}

Chien, Kenneth R. ^{[3
,4
]}

Laugwitz, Karl-Ludwig ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Med, D-81675 Munich, Germany

[2] Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany

[3] Karolinska Inst, Dept Cell & Mol Biol & Med, Stockholm, Sweden

[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2013年 / 3卷 / 10期

关键词：

CARDIAC NEURAL CREST; STEM-CELL DIFFERENTIATION; CORONARY-ARTERY FORMATION; SMOOTH-MUSCLE; CARDIOVASCULAR DEVELOPMENT; MAMMALIAN HEART; CARDIOMYOCYTE RENEWAL; LINEAGE COMMITMENT; SIGNALING PATHWAYS; SECONDARY HEART;

D O I：

10.1101/cshperspect.a013847

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). This review will focus on molecular cues necessary for proper induction, expansion, and lineage-specific differentiation of these progenitor populations during cardiac development in vivo. Moreover, we will briefly discuss how the knowledge gained on embryonic heart progenitor biology can be used to develop novel therapeutic strategies for the management of congenital heart disease as well as for improvement of cardiac function in ischemic heart disease.

引用

页数：17

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