Non-human primate surrogate model of hepatitis C virus infection

被引：14

作者：

Akari, Hirofumi ^{[1
]}

Iwasaki, Yuki ^{[1
]}

Yoshida, Tomoyuki ^{[1
]}

Iijima, Sayuki ^{[1
]}

机构：

[1] Natl Inst Biomed Innovat, Tsukuba Primate Res Ctr, Lab Dis Control, Tsukuba, Ibaraki 3050843, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2009年 / 53卷 / 01期

关键词：

GBV-B; HCV; hepatitis C; monkey; B INFECTION; IN-VIVO; GBV-B; VIRAL-HEPATITIS; CDNA-CLONE; HCV; TAMARINS; LIVER; GENERATION; MARMOSETS;

D O I：

10.1111/j.1348-0421.2008.00087.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

More than 170 million people worldwide are chronically infected by HCV, which is the causative agent of chronic hepatitis C, cirrhosis, and finally liver cancer. Although animal models of viral hepatitis are a prerequisite for the evaluation of antiviral and vaccine efficacy, the restricted host range of HCV has hampered the development of a suitable small animal model of HCV infection. Use of the chimpanzee, the only animal known to be susceptible to HCV infection, is limited by ethical and financial restrictions. In this regard GBV-B, being closely related to HCV, appears to be a promising non-human surrogate model for the study of HCV infection. This review describes the characteristic of GBV-B infection of New World monkeys, and discusses current issues concerning the GBV-B model and its future directions.

引用

收藏

页码：53 / 57

页数：5

相关论文

共 42 条

[1] Epidemiology of hepatitis C virus infection [J].

Alter, Miriam J. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (17) :2436-2441

[2] HIV/AIDS: in search of an animal model [J].

Ambrose, Zandrea ;

KewalRamani, Vineet N. ;

Bieniasz, Paul D. ;

Hatziioannou, Theodora .

TRENDS IN BIOTECHNOLOGY, 2007, 25 (08) :333-337

[3] Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles [J].

Bassett, SE ;

Brasky, KM ;

Lanford, RE .

JOURNAL OF VIROLOGY, 1998, 72 (04) :2589-2599

[4]

Beames B, 2001, ILAR J, V42, P152

[5] Development of a GB virus B marmoset model and its validation with a novel series of hepatitis C virus NS3 protease inhibitors [J].

Bright, H ;

Carroll, AR ;

Watts, PA ;

Fenton, RJ .

JOURNAL OF VIROLOGY, 2004, 78 (04) :2062-2071

[6] Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent [J].

Bukh, J ;

Apgar, CL ;

Yanagi, M .

VIROLOGY, 1999, 262 (02) :470-478

[7] Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees [J].

Bukh, J ;

Apgar, CL ;

Govindarajan, S ;

Purcell, RH .

JOURNAL OF MEDICAL VIROLOGY, 2001, 65 (04) :694-697

[8] Immunity against the GBV-B hepatitis virus in Tamarins can prevent productive infection following rechallenge and is long-lived [J].

Bukh, Jens ;

Engle, Ronald E. ;

Govindarajan, Sugantha ;

Purcell, Robert H. .

JOURNAL OF MEDICAL VIROLOGY, 2008, 80 (01) :87-94

[9] Five-year follow-up of patients with primary antibody deficiencies following an outbreak of acute hepatitis C [J].

Chapel, HM ;

Christie, JML ;

Peach, V ;

Chapman, RWG .

CLINICAL IMMUNOLOGY, 2001, 99 (03) :320-324

[10] Inhibition of hepatitis C virus infection in cell culture by small interfering RNAs [J].

Chevalier, Christophe ;

Saulnier, Aure ;

Benureau, Yann ;

Flechet, Dorian ;

Delgrange, David ;

Colbere-Garapin, Florence ;

Wychowski, Czeslaw ;

Martin, Annette .

MOLECULAR THERAPY, 2007, 15 (08) :1452-1462

← 1 2 3 4 5 →