Asbestos-like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization

被引：145

作者：

Ali-Boucetta, Hanene ^{[1
]}

Nunes, Antonio ^{[1
]}

Sainz, Raquel ^{[2
]}

Herrero, M. Antonia ^{[4
]}

Tian, Bowen ^{[1
]}

Prato, Maurizio ^{[3
]}

Bianco, Alberto ^{[2
]}

Kostarelos, Kostas ^{[1
]}

机构：

[1] UCL, UCL Sch Pharm, Nanomed Lab, London WC1N 1AX, England

[2] CNRS, Inst Biol Mol & Cellulaire, Lab Immunopathol & Chim Therapeut, F-67000 Strasbourg, France

[3] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[4] Univ Castilla La Mancha, Fac Quim, Dept Quim Organ, E-13071 Ciudad Real, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 08期

关键词：

graphene; carcinogenicity; inflammation; nanoparticles; toxicology; PARIETAL PLEURA; THERAPEUTICS; MESOTHELIOMA; EXCRETION; MICE; INFLAMMATION; RETENTION; INDUCTION; FIBERS; INJURY;

D O I：

10.1002/anie.201207664

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Sometimes shorter is better: The apparent similarity between multi-walled carbon nanotubes (MWNTs) and asbestos fibers has generated serious concerns about their safety profile. The asbestos-like pathogenicity observed for long, pristine nanotubes (NTlong, see scheme) can be completely alleviated if their effective length is decreased as a result of chemical functionalization, such as with tri(ethylene glycol) (TEG). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2274 / 2278

页数：5

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