Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst

被引：138

作者：

Bonomi, Renato ^{[1
,2
]}

Selvestrel, Francesco ^{[1
,2
]}

Lombardo, Valentina ^{[3
]}

Sissi, Claudia ^{[3
]}

Polizzi, Stefano ^{[4
]}

Mancin, Fabrizio ^{[1
,2
]}

Tonellato, Umberto ^{[1
,2
]}

Scrimin, Paolo ^{[1
,2
]}

机构：

[1] Univ Padua, Dipartimento Sci Chim, Padua, Italy

[2] Univ Padua, CNR, ITM, Padua, Italy

[3] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy

[4] Univ Venice, Dipartimento Chim Fis, I-30123 Venice, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 47期

关键词：

D O I：

10.1021/ja801794t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage

引用

页码：15744 / +

页数：3

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