Immunomodulatory properties of Cumaside

被引：54

作者：

Aminin, DL

Pinegin, BV

Pichugina, LV

Zaporozhets, TS

Agafonova, IG

Boguslavski, VM

Silchenko, AS

Avilov, SA

Stonik, VA

机构：

[1] Russian Acad Sci, Far Eastern Branch, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Dept Hlth, Natl Res Ctr, Inst Immunol, Moscow 115478, Russia

[3] RAMS, Siberian Branch, Res Inst Epidemiol & Microbiol, Vladivostok 690087, Russia

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2006年 / 6卷 / 07期

关键词：

cumaside; cucumariosides; holothurians; immunomodulatory activity;

D O I：

10.1016/j.intimp.2006.01.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides due to the glycoside-cholesterol complex formation. The influence of Cumaside on mouse macrophages in low doses was accompanied by more then two-fold stimulation of lysosomal activity. This preparation was found to increase significantly the animal resistance against bacterial infections elicited by various pathogens. It stimulated phagocytosis, ROS formation, IL6 and TNF-alpha production in lymphocytes, increased the number of antibody producing cells and amplified the expression of several cell surface molecules (CD3, CD4, CD8) preliminary cultured with hydrocortisone. At the same time the preparation did not affect the delayed-type hypersensitivity, proliferative activity of lymphocytes, cytotoxic activity of NK-cells and cytokine IFN gamma and IL12p70 release. The mechanism of Cumaside action is discussed. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1070 / 1082

页数：13

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