Inactivation of the p15(INK4B) and p16(INK4) genes in hematologic malignancies

被引：20

作者：

Heyman, M ^{[1
]}

Einhorn, S ^{[1
]}

机构：

[1] KAROLINSKA HOSP,RADIUMHEMMET,S-17176 STOCKHOLM,SWEDEN

来源：

LEUKEMIA & LYMPHOMA | 1996年 / 23卷 / 3-4期

关键词：

p16; p15; CDKN2; CDKN2B; ALL; leukemia; lymphoma;

D O I：

10.3109/10428199609054826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recently discovered p15(INK4B),d p16(INK4) genes encoding cell cycle regulating proteins, map to a region on chromosome 9p21 that is commonly deleted in a variety of malignant diseases. The p16(INK4) gene has now been shown to be a tumor suppressor gene. It is frequently inactivated in cancer and is possibly the second most often mutated gene in human malignant disease after p53. The role of the p15(INK4B) and p16(INK4) genes in hematologic malignancies has been the subject of intense investigation since their discovery. In this review we address the function and possible role in tumorigenesis of the p15(INK4B) and p16(INK4) genes and discuss their significance as prognostic markers in hematologic malignancies.

引用

页码：235 / 245

页数：11

共 161 条

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