Pharmacological management of ocular hypertension: current approaches and future prospective

被引：61

作者：

Bucolo, Claudio ^{[1
]}

Salomone, Salvatore ^{[1
]}

Drago, Filippo ^{[1
]}

Reibaldi, Michele ^{[2
]}

Longo, Antonio ^{[2
]}

Uva, Maurizio Giacinto ^{[2
]}

机构：

[1] Catania Univ, Dept Clin & Mol Biomed, Sect Pharmacol & Biochem, Catania, Italy

[2] Catania Univ, Dept Ophthalmol, Catania, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 01期

关键词：

LOWERS INTRAOCULAR-PRESSURE; OPEN-ANGLE GLAUCOMA; NITRIC-OXIDE; OUTFLOW FACILITY; BLOOD-FLOW; MELATONIN; MECHANISMS; RECEPTORS; AGONIST; INHIBITION;

D O I：

10.1016/j.coph.2012.09.012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Elevated eye pressure is the main risk factor for glaucoma, and intraocular pressure rises when the balance between aqueous humor formation and outflow resistance is compromised. In a normal eye there is a precise tune of aqueous outflow under the fine control of ciliary body and trabecular meshwork. Current pharmacological therapies for lowering the intraocular pressure in glaucoma include increasing aqueous humor outflow and suppression of aqueous humor production. However, most of antiglaucoma drugs currently on the market do not target the trabecular meshwork that represents the site of the pathology. This review focuses on pharmacological management of ocular hypertension with a particular attention to the future pharmacotherapy scenario.

引用

页码：50 / 55

页数：6

共 51 条

[1]

The role of melatonin in glaucoma: implications concerning pathophysiological relevance and therapeutic potential [J].

Agorastos, Agorastos ;

Huber, Christian G. .

JOURNAL OF PINEAL RESEARCH, 2011, 50 (01) :1-7

[2]

Melatonin receptors in the eye: Location, second messengers and role in ocular physiology [J].

Alarma-Estrany, Pilar ;

Pintor, Jesus .

PHARMACOLOGY & THERAPEUTICS, 2007, 113 (03) :507-522

[3]

Design of Novel Melatonin Analogs for the Reduction of Intraocular Pressure in Normotensive Rabbits [J].

Alarma-Estrany, Pilar ;

Guzman-Aranguez, Ana ;

Huete, Fernando ;

Peral, Assumpta ;

Plourde, Robert, Jr. ;

Pelaez, Teresa ;

Yerxa, Benjamin ;

Pintor, Jesus .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 337 (03) :703-709

[4]

Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse [J].

Alcantara-Contreras, Susana ;

Baba, Kenkichi ;

Tosini, Gianluca .

NEUROSCIENCE LETTERS, 2011, 494 (01) :61-64

[5]

In Vivo Evaluation of 11β-Hydroxysteroid Dehydrogenase Activity in the Rabbit Eye [J].

Anderson, Scott ;

Carreiro, Samantha ;

Quenzer, Terri ;

Gale, David ;

Xiang, Cathie ;

Gukasyan, Hovhannes ;

Lafontaine, Jennifer ;

Cheng, Hengmiao ;

Krauss, Achim ;

Prasanna, Ganesh .

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2009, 25 (03) :215-221

[6]

Effects of ibopamine eye drops on intraocular pressure and aqueous humor flow in healthy volunteers and patients with open-angle glaucoma [J].

Azevedo, H ;

Ciarniello, MG ;

Rosignoli, MT ;

Dioniso, P ;

Cunha-Vaz, J .

EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2003, 13 (04) :370-376

[7]

The Physiology, Signaling, and Pharmacology of Dopamine Receptors [J].

Beaulieu, Jean-Martin ;

Gainetdinov, Raul R. .

PHARMACOLOGICAL REVIEWS, 2011, 63 (01) :182-217

[8]

Advances in Glaucoma Treatment and Management: Gene Therapy [J].

Borras, Terete .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (05) :2506-2510

[9]

Dopamine-3 receptor modulates intraocular pressure: Implications for glaucoma [J].

Bucolo, Claudio ;

Leggio, Gian Marco ;

Maltese, Adriana ;

Castorina, Alessandro ;

D'Agata, Velia ;

Drag, Filippo .

BIOCHEMICAL PHARMACOLOGY, 2012, 83 (05) :680-686

[10]

Carbon monoxide and the eye: Implications for glaucoma therapy [J].

Bucolo, Claudio ;

Drago, Filippo .

PHARMACOLOGY & THERAPEUTICS, 2011, 130 (02) :191-201

← 1 2 3 4 5 6 →