Collagens in the progression and complications of atherosclerosis

被引：172

作者：

Adiguzel, Eser ^{[1
]}

Ahmad, Pamela J. ^{[1
]}

Franco, Christopher ^{[1
]}

Bendeck, Michelle P. ^{[1
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

来源：

VASCULAR MEDICINE | 2009年 / 14卷 / 01期

基金：

加拿大健康研究院;

关键词：

atherosclerosis; calcification; collagen; macrophage; plaque rupture; smooth muscle cell; SMOOTH-MUSCLE-CELLS; DISCOIDIN DOMAIN RECEPTOR-1; RETRACTED ARTICLE. SEE; ACTIVATED PROTEIN-KINASE; MONOCYTE-DERIVED MACROPHAGES; E-DEFICIENT MICE; MATRIX-METALLOPROTEINASE; EXTRACELLULAR-MATRIX; VIII COLLAGEN; VASCULAR CALCIFICATION;

D O I：

10.1177/1358863X08094801

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Collagens constitute a major portion of the extracellular matrix in the atherosclerotic plaque, where they contribute to the strength and integrity of the fibrous cap, and also modulate cellular responses via specific receptors and signaling pathways. This review focuses on the diverse roles that collagens play in atherosclerosis; regulating the infiltration and differentiation of smooth muscle cells and macrophages; controlling matrix remodeling through feedback signaling to proteinases; and influencing the development of atherosclerotic complications such as plaque rupture, aneurysm formation and calcification. Expanding our understanding of the pathways involved in cell-matrix interactions will provide new therapeutic targets and strategies for the diagnosis and treatment of atherosclerosis.

引用

页码：73 / 89

页数：17

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