Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

被引：96

作者：

Ohyama, M

Tanaka, T

Ito, T

Iinuma, M ^{[1
]}

Bastow, KF

Lee, KH

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Gifu Prefectural Inst Hlth & Environm Sci, Gifu 5008226, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00520-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 mu g/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 mu g/mL, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3057 / 3060

页数：4

相关论文

共 14 条

[1] Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model [J].

Carbó, N ;

Costelli, P ;

Baccino, FM ;

López-Soriano, FJ ;

Argilés, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 254 (03) :739-743

[2] Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway [J].

Huang, CS ;

Ma, WY ;

Goranson, A ;

Dong, ZG .

CARCINOGENESIS, 1999, 20 (02) :237-242

[3] Cancer chemopreventive activity of resveratrol, a natural product derived from grapes [J].

Jang, MS ;

Cai, EN ;

Udeani, GO ;

Slowing, KV ;

Thomas, CF ;

Beecher, CWW ;

Fong, HHS ;

Farnsworth, NR ;

Kinghorn, AD ;

Mehta, RG ;

Moon, RC ;

Pezzuto, JM .

SCIENCE, 1997, 275 (5297) :218-220

[4]

Ohyama M, 1998, CHEM PHARM BULL, V46, P663

[5] A NOVEL STILBENE TETRAMER, LEACHIANOL C, ISOLATED FROM SOPHORA-LEACHIANA [J].

OHYAMA, M ;

TANAKA, T ;

IINUMA, M .

TETRAHEDRON LETTERS, 1994, 35 (42) :7817-7820

[6] Davidiol D, first naturally occurring resveratrol pentamer isolated from Sophora davidii [J].

Ohyama, M ;

Ichise, M ;

Tanaka, T ;

Iinuma, M ;

Burandt, CL .

TETRAHEDRON LETTERS, 1996, 37 (29) :5155-5158

[7] 5 RESVERATROL OLIGOMERS FROM ROOTS OF SOPHORA-LEACHIANA [J].

OHYAMA, M ;

TANAKA, T ;

IINUMA, M .

PHYTOCHEMISTRY, 1995, 38 (03) :733-740

[8]

OHYAMA M, 1994, CHEM PHARM BULL, V42, P2117

[9] COMPARISON OF INVITRO ANTICANCER-DRUG-SCREENING DATA GENERATED WITH A TETRAZOLIUM ASSAY VERSUS A PROTEIN ASSAY AGAINST A DIVERSE PANEL OF HUMAN TUMOR-CELL LINES [J].

RUBINSTEIN, LV ;

SHOEMAKER, RH ;

PAULL, KD ;

SIMON, RM ;

TOSINI, S ;

SKEHAN, P ;

SCUDIERO, DA ;

MONKS, A ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) :1113-1118

[10] DISTRIBUTION OF RESVERATROL OLIGOMERS IN PLANTS [J].

SOTHEESWARAN, S ;

PASUPATHY, V .

PHYTOCHEMISTRY, 1993, 32 (05) :1083-1092