Seven-transmembrane receptors: crystals clarify

被引：140

作者：

Lu, ZL

Saldanha, JW

Hulme, EC

机构：

[1] MRC, Ctr Reprod Biol, Reprod Biol Unit, Edinburgh, Midlothian, Scotland

[2] Natl Inst Med Res, Div Phys Biochem, London NW7 1AA, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0165-6147(00)01973-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

dThe X-ray structure of the photo receptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled receptor. This has provided an improved template for interpreting the huge body of structure-activity, mutagenesis and affinity labelling data available for related 7-TM receptors, such as muscarinic acetylcholine receptors. Ligand contacts, and the intramolecular interactions that stabilize the ground state structure, can be identified with some degree of confidence. We now have a firm basis for attempts to predict the structure of the receptor-G-protein complex, and understand the mechanism by which the agonist-receptor complex activates the G protein.

引用

收藏

页码：140 / 146

页数：7

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