Seven-transmembrane receptors: crystals clarify

被引：140

作者：

Lu, ZL

Saldanha, JW

Hulme, EC

机构：

[1] MRC, Ctr Reprod Biol, Reprod Biol Unit, Edinburgh, Midlothian, Scotland

[2] Natl Inst Med Res, Div Phys Biochem, London NW7 1AA, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0165-6147(00)01973-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

dThe X-ray structure of the photo receptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled receptor. This has provided an improved template for interpreting the huge body of structure-activity, mutagenesis and affinity labelling data available for related 7-TM receptors, such as muscarinic acetylcholine receptors. Ligand contacts, and the intramolecular interactions that stabilize the ground state structure, can be identified with some degree of confidence. We now have a firm basis for attempts to predict the structure of the receptor-G-protein complex, and understand the mechanism by which the agonist-receptor complex activates the G protein.

引用

页码：140 / 146

页数：7

共 79 条

[71] The sequence of the human genome [J].

Venter, JC ;

Adams, MD ;

Myers, EW ;

Li, PW ;

Mural, RJ ;

Sutton, GG ;

Smith, HO ;

Yandell, M ;

Evans, CA ;

Holt, RA ;

Gocayne, JD ;

Amanatides, P ;

Ballew, RM ;

Huson, DH ;

Wortman, JR ;

Zhang, Q ;

Kodira, CD ;

Zheng, XQH ;

Chen, L ;

Skupski, M ;

Subramanian, G ;

Thomas, PD ;

Zhang, JH ;

Miklos, GLG ;

Nelson, C ;

Broder, S ;

Clark, AG ;

Nadeau, C ;

McKusick, VA ;

Zinder, N ;

Levine, AJ ;

Roberts, RJ ;

Simon, M ;

Slayman, C ;

Hunkapiller, M ;

Bolanos, R ;

Delcher, A ;

Dew, I ;

Fasulo, D ;

Flanigan, M ;

Florea, L ;

Halpern, A ;

Hannenhalli, S ;

Kravitz, S ;

Levy, S ;

Mobarry, C ;

Reinert, K ;

Remington, K ;

Abu-Threideh, J ;

Beasley, E .

SCIENCE, 2001, 291 (5507) :1304-+

[72] Activation of guanosine 5′-[γ-35S]thio-triphosphate binding through M1 muscarinic receptors in transfected Chinese hamster ovary cell membranes:: 2.: Testing the "two-states" model of receptor activation [J].

Waelbroeck, M .

MOLECULAR PHARMACOLOGY, 2001, 59 (04) :886-893

[73] Activation of guanosine 5′-[γ-35S]thio-triphosphate binding through M1 muscarinic receptors in transfected Chinese hamster ovary cell membranes:: 1.: Mathematical analysis of catalytic G protein activation [J].

Waelbroeck, M .

MOLECULAR PHARMACOLOGY, 2001, 59 (04) :875-885

[74] Alanine-scanning mutagenesis of transmembrane domain 6 of the M1 muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function [J].

Ward, SDC ;

Curtis, CAM ;

Hulme, EC .

MOLECULAR PHARMACOLOGY, 1999, 56 (05) :1031-1041

[75] MOLECULAR-BASIS OF MUSCARINIC ACETYLCHOLINE-RECEPTOR FUNCTION [J].

WESS, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (08) :308-313

[76] Molecular biology of muscarinic acetylcholine receptors [J].

Wess, J .

CRITICAL REVIEWS IN NEUROBIOLOGY, 1996, 10 (01) :69-99

[77] Identification of Gβγ binding sites in the third intracellular loop of the M3-muscarinic receptor and their role in receptor regulation [J].

Wu, GY ;

Bogatkevich, GS ;

Mukhin, YV ;

Benovic, JL ;

Hildebrandt, JD ;

Lanier, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :9026-9034

[78] State-dependent disulfide cross-linking in rhodopsin [J].

Yu, HB ;

Kono, M ;

Oprian, DD .

BIOCHEMISTRY, 1999, 38 (37) :12028-12032

[79] Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling [J].

Zeng, FY ;

Soldner, A ;

Schöneberg, T ;

Wess, J .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (06) :2404-2414

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