Suppression of endothelin system in Vero cells latently infected with influenza virus B/Lee/40 - Brief report

被引：3

作者：

Hayase, Y ^{[1
]}

Tobita, K ^{[1
]}

机构：

[1] Jichi Med Sch, Dept Virol, Minami Kawachi, Tochigi 3290498, Japan

来源：

ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 07期

关键词：

D O I：

10.1007/s007050050598

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Vero cells latently infected with influenza virus B/Lee/40 (LN cells), the endothelin (ET) system was examined as a possible mediator in pathogenesis of latent viral infection by radioimmunoassay (RIA) and quantitative reverse transcription polymerase reaction (RT-PCR). During viral latency of more than two months, ET secretion, preproendothelin-l (PPET-1) mRNA, and endothelin receptor subtype A (ETAR) mRNA within the cells remained suppressed. Our data indicate that not only the release of ET-1 was downregulated at the transcriptional level but also ETAR mRNA was downregulated rather than upregulated compensatively in L/V cells.

引用

页码：1421 / 1427

页数：7

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