Antioxidant properties in cashew apple byproduct (Anacardium occidentale L.): effect on lipoperoxidation and on the polyunsaturated fatty acids profile in rats

被引：9

作者：

Bolelli Broinizi, Priscila Regina ^{[1
]}

Silva de Andrade-Wartha, Elma Regina

Mara de Oliveira e Silva, Ana ^{[1
]}

Torres, Rosangela Pavan ^{[1
]}

Cordeiro Azeredo, Henriette Monteiro ^{[2
]}

Alves, Ricardo Elesbao ^{[2
]}

Mancini-Filho, Jorge ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr & Expt, BR-05508900 Sao Paulo, Brazil

[2] EMBRAPA, Ctr Nacl Pesquisa Agroind Trop, Brasilia, DF, Brazil

来源：

REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS | 2008年 / 44卷 / 04期

关键词：

Cashew apple; DPPH; Lipoperoxidation; Polyunsaturated fatty acids (PUFAs); Docosahexaenoic acid (DHA);

D O I：

10.1590/S1516-93322008000400025

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The cashew apple (Anacardium occidentale L.) contains phenolic compounds usually related with antioxidant properties. Then, the aim of this study was to investigate its antioxidant capacity. The antioxidant capacity of the hydroalcoholic extract of the cashew apple pulp (EHAlc.) was assessed for the scavenging of the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) by in vitro method and by an in vivo essay. For this essay a 30-day oral (gavage, EHAlc. 200 and 400 mg/kg) study was conducted in Wistar male rats, evaluating hepatic, plasma and brain tissues. In DPPH model, the extract demonstrated antioxidant activity of 95% (largest concentration, 1000 mu g/mL). There were found no relevant peroxidation comparing the treated animals with the control group. However, the treated group presented a lower level of brain lipoperoxidation. Also in the treated animals brain tissue was found the largest amount of polyunsaturated fatty acids (PUFA), mainly docosahexaenoic (DHA). Therqfore, the analyzed extract from cashew apple pulp clone CCP-76 contains effective natural antioxidants, responsible for free radical scavenging in vitro and also for decreasing the brain lipoperoxidation and keeping the PUFAS levels in Wistar rats.

引用

页码：773 / 781

页数：9

共 30 条

[1]

ANDRADEWARTHA ERS, 2007, THESIS U SAO PAULO

[2]

*ASS OFF AN CHEM, 2002, OFF METH AN AOAC, P20

[3]

Analysis of lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids [J].

Aust, O ;

Sies, H ;

Stahl, W ;

Polidori, MC .

JOURNAL OF CHROMATOGRAPHY A, 2001, 936 (1-2) :83-93

[4]

Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract [J].

Balu, M ;

Sangeetha, P ;

Haripriya, D ;

Panneerselvam, C .

NEUROSCIENCE LETTERS, 2005, 383 (03) :295-300

[5]

The importance of essential fatty acids and the effect of trans fatty acids in human milk on fetal and neonatal development [J].

Barboza Tinoco, Sandra Manzato ;

Sichieri, Rosely ;

Moura, Anibal Sanchez ;

Santos, Fldvia da Silva ;

Tavares do Carmo, Maria das Gracas .

CADERNOS DE SAUDE PUBLICA, 2007, 23 (03) :525-534

[6]

ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[7]

Evaluation of the antioxidant activity of phenolic compounds naturally contained in by-products of the cashew apple (Anacardium occidentale L.) [J].

Bolelli Broinizi, Priscila Regina ;

Silva de Andrade-Wartha, Elma Regina ;

de Oliveira e Silva, Ana Mara ;

Vidal Novoa, Axis Jesfis ;

Torres, Rosangela Pavan ;

Cordeiro Azeredo, Henriette Monteiro ;

Alves, Ricardo Elesbao ;

Mancini-Filho, Jorge .

CIENCIA E TECNOLOGIA DE ALIMENTOS, 2007, 27 (04) :902-908

[8]

BRAND-WILLIAMS W, 1995, FOOD SCI TECHNOL-LEB, V28, P25

[9]

Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory [J].

Das, UN .

NUTRITION, 2003, 19 (01) :62-65

[10]

Dean RT, 1997, BIOCHEM J, V324, P1

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