Amino-terminal pro-B-type natriuretic peptide: Analytic considerations

被引：59

作者：

Ordonez-Llanos, Jordi ^{[3
,4
]}

Collinson, Paul O. ^{[5
]}

Christenson, Robert H. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Med Ctr, Rapid Response Labs, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Pathol & Med Res & Technol, Baltimore, MD 21201 USA

[3] Univ Autonoma Barcelona, Serv Biochem, Hosp Santa Creu & Sant Pau, E-08193 Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Biochem & Mol Biol, E-08193 Barcelona, Spain

[5] St George Hosp, Dept Chem Pathol, London, England

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2008年 / 101卷 / 3A期

关键词：

D O I：

10.1016/j.amjcard.2007.11.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is a convenient molecule to work with in clinical laboratories, with preanalytic and analytic advantages, such as excellent stability at different temperatures, flexibility in sample type, and strong harmony across all commercially available NT-proBNP assays (including recently released point-of-care methods). Another major advantage of NT-proBNP assays is that they show excellent analytic precision. Reference values for NT-proBNP testing are strongly affected by the population tested. Among nondiseased populations, lower values are expected, whereas in diseased populations, such as in patients with acute dyspnea, higher reference values are more useful. Also, the biologic variability of NT-proBNP should be taken into account to evaluate the significance of any change in its values. When analyzed in patients with stable heart failure, biologic variability was 25% - 40%. This article reviews the laboratory aspects of NT-proBNP testing from the perspective of the clinical laboratorian. (c) 2008 Elsevier.Inc. All rights reserved.

引用

页码：9A / 15A

页数：7

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