Pentafluorophenyl sulfonate ester as a protecting group for the preparation of biaryl- and heterobiaryl sulfonate esters

被引：21

作者：

Avitabile, BG ^{[1
]}

Smith, CA ^{[1
]}

Judd, DB ^{[1
]}

机构：

[1] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 05期

关键词：

D O I：

10.1021/ol047422o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of the pentafluorophenyl (PFP) group as a sulfonic acid protecting group has allowed the synthesis of new biaryl- and heterobiaryl-PFP-sulfonate esters by use of the Suzuki-Miyaura reaction. The successful employment of a novel inorganic base, anhydrous sodium tetraborate, was crucial to give the products in excellent yields. The PFP-sulfonate ester has been previously shown to be an excellent alternative to sulfonyl chlorides in the synthesis of sulfonamides.

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页码：843 / 846

页数：4

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