Synthesis and lithiation of oxazolinylaziridines:: the N-substituent effect

被引：37

作者：

Luisi, R

Capriati, V

Florio, S

Di Cunto, P

Musio, B

机构：

[1] Univ Bari, Dipartimento Farmacochim, I-70126 Bari, Italy

[2] CNR, ICCOM, Sez Bari, I-70126 Bari, Italy

来源：

TETRAHEDRON | 2005年 / 61卷 / 13期

关键词：

aziridinyllithiums; oxazolinylaziridines; aziridino-gamma-lactones; lithiation;

D O I：

10.1016/j.tet.2005.01.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of N-substituted oxazolinylaziridines and their deprotonation to afford the corresponding aziridinyllithiums is described. The chemical and configurational stability of the lithiated species depends on the N-substituent on the aziridine ring. The trapping with carbonyl compounds of (R*,S*) configurated oxazolinylaziridines is an interesting route for the preparation of functionalised alpha,beta-aziridino-gamma-lactones. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3251 / 3260

页数：10

共 34 条

[21] 2-benzotriazolylaziridines and their reactions with diethyl acetylenedicarboxylate [J].