Nanotechnological strategies for engineering complex tissues

被引：556

作者：

Dvir, Tal ^{[1
,2
]}

Timko, Brian P. ^{[2
,3
]}

Kohane, Daniel S. ^{[2
]}

Langer, Robert ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Harvard Univ, Lab Biomat & Drug Delivery, Childrens Hosp Boston, Div Crit Care Med,Sch Med,Dept Anesthesiol, Boston, MA 02115 USA

[3] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

NATURE NANOTECHNOLOGY | 2011年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

EXTRACELLULAR-MATRIX; CARBON NANOTUBES; ALGINATE HYDROGELS; DELIVERY-SYSTEM; RGD PEPTIDE; IN-VITRO; SCAFFOLDS; CELLS; NANOSCALE; DIFFERENTIATION;

D O I：

10.1038/NNANO.2010.246

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.

引用

页码：13 / 22

页数：10

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