Shish-Kebab-Structured Poly(ε-Caprolactone) Nanofibers Hierarchically Decorated with Chitosan Poly(ε-Caprolactone) Copolymers for Bone Tissue Engineering

被引：147

作者：

Jing, Xin ^{[1
,2
]}

Mi, Hao-Yang ^{[1
,2
]}

Wang, Xin-Chao ^{[3
]}

Peng, Xiang-Fang ^{[1
]}

Turng, Lih-Sheng ^{[2
]}

机构：

[1] S China Univ Technol, Minist Educ, Key Lab Polymer Proc Engn, Natl Engn Res Ctr Novel Equipment Polymer Proc, Guangzhou 510640, Guangdong, Peoples R China

[2] Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI 53715 USA

[3] Zhengzhou Univ, Natl Engn Res Ctr Adv Polymer Proc Technol, Zhengzhou 450002, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 12期

关键词：

poly(epsilon-caprolactone)(PCL); chitosan (CS); electrospinning; shish-kebab structure; tissue engineering; CALCIUM-PHOSPHATE; CELL-ADHESION; SURFACE MODIFICATION; COMPOSITE SCAFFOLDS; COLLAGEN FIBRILS; IN-VITRO; POLYCAPROLACTONE; FABRICATION; GELATIN; BLENDS;

D O I：

10.1021/acsami.5b00900

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

In this work, scaffolds with a shish-kebab (SK) structure formed by poly(epsilon-caprolactone) (PCL) nanofibers and chitosan-PCL (CS-PCL) copolymers were prepared via electrospinning and subsequent crystallization for bone tissue engineering applications. The aim of this study was to introduce nanosized topography and the high biocompatibility of chitosan onto PCL nanofibers to enhance cell affinity to PCL scaffolds. CS-PCL copolymers with various ratios were synthesized, and then spontaneously crystallized as kebabs onto the electrospun PCL fibers, which acted as shishes. Scanning electron microscopy (SEM) results demonstrated that the copolymer with PCL to chitosan ratio of 8.8 could hierarchically decorate the PCL nanofibers and formed well-shaped kebabs on the PCL nanofiber surface. Water contact angle tests and biomimetic activity experiments revealed that the shish-kebab scaffolds with CS-PCL kebabs (PCL-SK(CS-PCL8.8)) showed enhanced hydrophilicity and mineralization ability compared with smooth PCL and PCL-SK(PCL) shish-kebab scaffolds. Osteoblast-like MG63 cells cultured on the PCL-SK(CS-PCL8.8) scaffolds showed optimizing cell attachment, cell viability, and metabolic activity, demonstrating that this kind of scaffold has potential applications in bone tissue engineering.

引用

页码：6955 / 6965

页数：11

共 54 条

[1]

Significantly Improving Oxygen Barrier Properties of Polylactide via Constructing Parallel-Aligned Shish-Kebab-Like Crystals with Well-Interlocked Boundaries [J].