Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases

被引:31
作者
Dilkes, MG [1 ]
Benjamin, E [1 ]
Ovaisi, S [1 ]
Banerjee, AS [1 ]
机构
[1] St Bartholomews Hosp, Dept Otolaryngol HNS, London EC1Y 0DT, England
关键词
head and neck neoplasms; photochemotherapy; treatment outcome;
D O I
10.1258/002221503322334558
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The use of photodynamic therapy for the treatment of malignant and non-malignant conditions is increasing. This paper demonstrates the efficacy of a second-generation photosensitizer, Foscan((R)), in the primary treatment of a wide range of mucosal head and neck squamous cell carcinomas. Tumours ranged in stage from T-1 to T-3. A complete response to primary treatment was seen in 19/21 patients (90 per cent). In laryngeal cancer recurrent after radical radiotherapy, one out of four patients treated obtained a complete response (25 per cent). Six patients (24 per cent) required surgery after photodynamic therapy, for local recurrence or dysplasia. Mean follow up was for 27.3 months (standard deviation 20.6 months).
引用
收藏
页码:713 / 717
页数:5
相关论文
共 13 条
[11]   PHOTOFRIN-mediated photodynamic therapy for treatment of early stage oral cavity and laryngeal malignancies [J].
Schweitzer, VG .
LASERS IN SURGERY AND MEDICINE, 2001, 29 (04) :305-313
[12]   ENDOSCOPIC ULTRASONOGRAPHY IN THE PREOPERATIVE STAGING OF ESOPHAGEAL CANCER [J].
SOUQUET, JC ;
NAPOLEON, B ;
PUJOL, B ;
KERIVEN, O ;
PONCHON, T ;
DESCOS, F ;
LAMBERT, R .
ENDOSCOPY, 1994, 26 (09) :764-766
[13]   RESULTS OF CURATIVE LASER MICROSURGERY OF LARYNGEAL CARCINOMAS [J].
STEINER, W .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 1993, 14 (02) :116-121