A novel building block for the synthesis of isofagomin analogues

被引：15

作者：

Altenbach, HJ ^{[1
]}

Blanda, G ^{[1
]}

机构：

[1] Berg Univ Gesamthsch Wuppertal, Fachbereich Chem, D-42119 Wuppertal, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0957-4166(98)00090-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The de novo synthesis of the novel potent building blocks phenyl (R)-3-acetoxymethyl-3,6-dihydro-2H-pyrid 1-carboxylate (-)-7 and phenyl (S)-3-butyryl-oxymethyl-3,6-dihydro-2H-pyridine-1-carboxylate (+)-8 starting from commercially available methyl-1-benzyl-4-oxo-3-piperidinecarboxylate is described. The key steps are the enantioselective esterification of the racemic alcohol 6 and the enantioselective hydrolysis of the racemic acetate 5, respectively, using lipase P from Pseudomonas caepacia. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1519 / 1524

页数：6

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