A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells

被引：167

作者：

Du, Pingwu ^{[1
]}

Lippard, Stephen J. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

INORGANIC CHEMISTRY | 2010年 / 49卷 / 23期

关键词：

CHEMOSENSOR; PROBE; ZN2+; CHEMODOSIMETER; NEUROBIOLOGY; CU(II); ION;

D O I：

10.1021/ic101569a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Cd2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels.

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收藏

页码：10753 / 10755

页数：3

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