Neuroprotective properties of resveratrol and derivatives

被引：159

作者：

Richard, Tristan ^{[1
]}

Pawlus, Alison D. ^{[1
]}

Iglesias, Marie-Laure ^{[1
]}

Pedrot, Eric ^{[1
]}

Waffo-Teguo, Pierre ^{[1
]}

Merillon, Jean-Michel ^{[1
]}

Monti, Jean-Pierre ^{[1
]}

机构：

[1] Univ Bordeaux, GESVAB EA 3675, ISVV Bordeaux Aquitaine, F-33883 Villenave Dornon, France

来源：

RESVERATROL AND HEALTH | 2011年 / 1215卷

关键词：

stilbenoid; Alzheimer's disease; beta-amyloid peptide; inhibition of aggregation; AMYLOID-INDUCED NEUROTOXICITY; ALZHEIMERS-DISEASE; IN-VITRO; A-BETA; PROTEIN; INVOLVEMENT; OLIGOMERS; FIBRILS; NEURONS; DEATH;

D O I：

10.1111/j.1749-6632.2010.05865.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Stilbenoid compounds consist of a family of resveratrol derivatives. They have demonstrated promising activities in vitro and in vivo that indicate they may be useful in the prevention of a wide range of pathologies, such as cardiovascular diseases and cancers, as well have anti-aging effects. More recently stilbenoid compounds have shown promise in the treatment and prevention of neurodegenerative disorders, such as Huntington's, Parkinson's, and Alzheimer's diseases. This paper primarily focuses on the impact of stilbenoids in Alzheimer's disease and more specifically on the inhibition of beta-amyloid peptide aggregation.

引用

页码：103 / 108

页数：6

共 32 条

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Resveratrol - A boon for treating Alzheimer's disease? [J].