Buccal delivery systems

被引：105

作者：

Hao, JS ^{[1
]}

Heng, PWS ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2003年 / 29卷 / 08期

关键词：

buccal delivery; bioadhesion; penetration enhancer; enzyme inhibitor; formulation design;

D O I：

10.1081/DDC-120024178

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The oral cavity is an attractive site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism. Buccal drug delivery specifically refers to the delivery of drugs within/ through buccal mucosa to affect local/systemic pharmacological actions. This review briefly describes advantages and limitations of buccal drug delivery, anatomical structure of oral mucosa, and methodology in evaluating buccal drug delivery system, focusing of physiology, pharmacology, pathology, and formulation design in line with recent developments in buccal delivery systems.

引用

页码：821 / 832

页数：12

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