Evaluation of the Mean and Entropy of Apparent Diffusion Coefficient Values in Chronic Hepatitis C: Correlation with Pathologic Fibrosis Stage and Inflammatory Activity Grade

被引：113

作者：

Fujimoto, Kiminori ^{[1
,6
]}

Tonan, Tatsuyuki ^{[1
]}

Azuma, Sanae ^{[1
]}

Kage, Masayoshi ^{[2
]}

Nakashima, Osamu ^{[3
]}

Johkoh, Takeshi ^{[7
]}

Hayabuchi, Naofumi ^{[1
]}

Okuda, Koji ^{[5
]}

Kawaguchi, Takumi ^{[4
]}

Sata, Michio ^{[4
]}

Qayyum, Aliya ^{[8
]}

机构：

[1] Kurume Univ, Sch Med, Dept Radiol, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Diagnost Pathol, Kurume, Fukuoka 8300011, Japan

[3] Kurume Univ, Sch Med, Dept Pathol, Kurume, Fukuoka 8300011, Japan

[4] Kurume Univ, Sch Med, Dept Digest Dis Informat & Res, Kurume, Fukuoka 8300011, Japan

[5] Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 8300011, Japan

[6] Kurume Univ Hosp, Ctr Diagnost Imaging, Kurume, Fukuoka, Japan

[7] Kinki Cent Hosp, Mutual Aid Assoc Publ Sch Teachers, Dept Radiol, Itami, Hyogo, Japan

[8] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

来源：

RADIOLOGY | 2011年 / 258卷 / 03期

关键词：

LIVER FIBROSIS; MULTIPLE-SCLEROSIS; OBSERVER AGREEMENT; WEIGHTED MRI; DIAGNOSIS; CIRRHOSIS; ELASTOGRAPHY; DISEASE;

D O I：

10.1148/radiol.10100853

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To determine whether mean and entropy apparent diffusion coefficient (ADC) values obtained at diffusion-weighted (DW) magnetic resonance (MR) imaging can help detect and stage histopathologic liver fibrosis and grade inflammation activity in patients with chronic hepatitis C. Materials and Methods: This retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. The study included 55 patients with focal hepatic lesions and either chronic hepatitis C (n = 43) or normal hepatic function (control subjects) (n = 12). Mean and entropy of volume histograms were generated in four cubic regions of interest placed in the right hepatic lobe of ADC map images, which were obtained at echoplanar DW MR imaging (gradient factor b values of 0 and 1000 sec/mm(2)). These two parameters (mean and entropy ADC) were compared by using METAVIR histopathologic liver fibrosis and inflammatory activity scores. Statistical analysis was performed with the Kruskal-Wallis test and receiver operating characteristic curves. Results: The mean ADC decreased with an increase in the fibrosis stage or inflammatory activity grade, and the entropy ADC increased with an increase in the fibrosis stage or inflammatory activity grade (P < .001 for all comparisons, Kruskal-Wallis test). The area under the receiver operating characteristic curve (A(z)) for the mean ADC was statistically significant in the differentiation of fibrosis stage or inflammatory activity grade (A(z), 0.807-0.926; P < .001 for all comparisons). Entropy of ADC was helpful for classifying normal from abnormal fibrosis stage or inflammatory activity grade (A(z) for both parameters, 0.937; P < .001). Conclusion: Assessment of a combination of mean ADC and entropy ADC in patients with chronic hepatitis C is more accurate for predicting pathologic hepatic fibrosis stage and inflammatory activity grade and helpful for detecting early fibrotic or inflammatory activity when compared with assessment of mean ADC alone. (C)RSNA, 2011

引用

页码：739 / 748

页数：10

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