Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

被引：201

作者：

Avila, Matias A. ^{[1
]}

Dufour, Jean-Francois ^{[2
,3
]}

Gerbes, Alexander L. ^{[4
]}

Zoulim, Fabien ^{[5
]}

Bataller, Ramon ^{[6
]}

Burra, Patrizia ^{[7
]}

Cortez-Pinto, Helena ^{[8
]}

Gao, Bin ^{[9
]}

Gilmore, Ian ^{[10
]}

Mathurin, Philippe ^{[11
]}

Moreno, Christophe ^{[12
]}

Poznyak, Vladimir ^{[13
]}

Schnabl, Bernd ^{[14
]}

Szabo, Gyongyi ^{[15
]}

Thiele, Maja ^{[16
,17
,18
]}

Thursz, Mark R. ^{[19
]}

机构：

[1] Univ Navarra, IdiSNA, CIMA, Hepatol,CIBERehd, Pamplona, Spain

[2] Univ Bern, Inselspital, Dept Clin Res, Hepatol, Bern, Switzerland

[3] Univ Bern, Univ Clin Visceral Surg & Med, Inselspital, Bern, Switzerland

[4] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 2, Liver Ctr Munich, Munich, Germany

[5] Univ Lyon, Canc Res Cent Lyon, Hosp Civils Lyon, Hepatol Dept,INSERM,U1052, Lyon, France

[6] Univ Pittsburgh, Dept Med, Pittsburgh Liver Res Ctr, Divs Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA

[7] Padua Univ Hosp, Dept Surg Oncol & Gastroenterol, Multivisceral Transplant Unit, Gastroenterol, Padua, Italy

[8] Univ Lisbon, Fac Med, Lab Nutr, Dept Gastroenterol,CHLN, Lisbon, Portugal

[9] NIAAA, Lab Liver Dis, NIH, Bethesda, MD USA

[10] Univ Liverpool, Liverpool Ctr Alcohol Res, Liverpool, Merseyside, England

[11] Hop Huriez, INSERM, U795, Serv Malad Appareil Digestif, Lille, France

[12] Univ Libre Bruxelles, CUB Hop Erasme, Serv Gastroenterol Hepatopancreatol & Oncol Diges, Brussels, Belgium

[13] WHO, Dept Mental Hlth & Subst Abuse, Geneva, Switzerland

[14] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[15] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[16] Odense Univ Hosp, Dept Gastroenterol & Hepatol, Odense, Denmark

[17] Odense Univ Hosp, Dept Clin Res, Odense, Denmark

[18] Univ Southern Denmark, Odense, Denmark

[19] Imperial Coll, Dept Metab, Fac Med, London, England

来源：

GUT | 2020年 / 69卷 / 04期

基金：

英国医学研究理事会;

关键词：

COLONY-STIMULATING FACTOR; ACUTE KIDNEY INJURY; INFLAMMASOME ACTIVATION; DANGER SIGNALS; MURINE MODEL; RISK-FACTORS; MOUSE MODEL; URIC-ACID; TRANSPLANTATION; HEPATITIS;

D O I：

10.1136/gutjnl-2019-319720

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area. In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.

引用

页码：764 / 780

页数：17

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