Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

被引:90
作者
Fletcher, Steven [1 ]
Turkson, James [2 ]
Gunning, Patrick T. [1 ]
机构
[1] Univ Toronto, Dept Chem, Mississauga, ON L5L 1C6, Canada
[2] Univ Cent Florida, Burnett Coll Biomed Sci, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA
关键词
antitumor agents; peptidomimetics; protein-protein interactions; small molecules; stat3;
D O I
10.1002/cmdc.200800123
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1159 / 1168
页数:10
相关论文
共 53 条
  • [1] Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer - Modern target but ancient solution
    Aggarwal, Bharat B.
    Sethi, Gautam
    Ahn, Kwang Seok
    Sandur, Santosh K.
    Pandey, Manoj K.
    Kunnumakkara, Ajaikumar B.
    Sung, Bokyung
    Ichikawa, Haruyo
    [J]. SIGNAL TRANSDUCTION PATHWAYS, PT B: STRESS SIGNALING AND TRANSCRIPTIONAL CONTROL, 2006, 1091 : 151 - 169
  • [2] Barton BE, 2004, MOL CANCER THER, V3, P11
  • [3] Three-dimensional structure of the Stat3β homodimer bound to DNA
    Becker, S
    Groner, B
    Müller, CW
    [J]. NATURE, 1998, 394 (6689) : 145 - 151
  • [4] Signal transducers and activators of transcription as targets for small organic molecules
    Berg, Thorsten
    [J]. CHEMBIOCHEM, 2008, 9 (13) : 2039 - 2044
  • [5] Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    Berishaj, Marjan
    Gao, Sizhi Paul
    Ahmed, Simi
    Leslie, Kenneth
    Al-Ahmadie, Hikmat
    Gerald, William L.
    Bornmann, William
    Bromberg, Jacqueline F.
    [J]. BREAST CANCER RESEARCH, 2007, 9 (03)
  • [6] Biomolecular Targets for Platinum Antitumor Drugs
    Bose, Rathindra N.
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2002, 2 (02) : 103 - 111
  • [7] STATs in oncogenesis
    Bowman, T
    Garcia, R
    Turkson, J
    Jove, R
    [J]. ONCOGENE, 2000, 19 (21) : 2474 - 2488
  • [8] Buettner R, 2002, CLIN CANCER RES, V8, P945
  • [9] Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    Burke, WM
    Jin, XH
    Lin, HJ
    Huang, M
    Liu, R
    Reynolds, RK
    Lin, JY
    [J]. ONCOGENE, 2001, 20 (55) : 7925 - 7934
  • [10] CAILLEAU R, 1978, IN VITRO CELL DEV B, V14, P911