Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

被引:90
作者
Fletcher, Steven [1 ]
Turkson, James [2 ]
Gunning, Patrick T. [1 ]
机构
[1] Univ Toronto, Dept Chem, Mississauga, ON L5L 1C6, Canada
[2] Univ Cent Florida, Burnett Coll Biomed Sci, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA
关键词
antitumor agents; peptidomimetics; protein-protein interactions; small molecules; stat3;
D O I
10.1002/cmdc.200800123
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1159 / 1168
页数:10
相关论文
共 53 条
  • [51] Stat-3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
    WeberNordt, RM
    Riley, JK
    Greenlund, AC
    Moore, KW
    Darnell, JE
    Schreiber, BD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) : 27954 - 27961
  • [52] The stats of cancer - New molecular targets come of age
    Yu, H
    Jove, R
    [J]. NATURE REVIEWS CANCER, 2004, 4 (02) : 97 - 105
  • [53] PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
    Zhang, Sheng
    Zhang, Zhong-Yin
    [J]. DRUG DISCOVERY TODAY, 2007, 12 (9-10) : 373 - 381