Adenosine, mast cells and asthma

被引:79
作者
Forsythe, P [1 ]
Ennis, M [1 ]
机构
[1] Queens Univ Belfast, Dept Clin Biochem, Belfast BT12 6BJ, Antrim, North Ireland
关键词
mast cells; adenosine; asthma;
D O I
10.1007/s000110050464
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The aim of this article is to review the interplay between adenosine and mast cells in asthma. Adenosine is an endogenous nucleoside released from metabolically active cells and generated extracellularly via the degradation of released ATP. It is a potent biological mediator that modulates the activity of numerous cell types including platelets, neutrophils and mast cells via action at specific adenosine receptors (A(1), A(2a), A(2b), A(3)). These receptors are expressed on mast cells but the exact pattern of receptor subtype expression depends on the source of the mast cells. Adenosine is also a potent bronchoconstricting agent and is suggested to contribute to the pathophysiology of asthma. Evidence is provided to suggest that the nucleoside exerts its influence on the asthmatic condition through its ability to modulate the release of mast cell derived mediators. However, the mechanism of adenosine/mast cell interaction which contributes to asthma remains unclear. Progress in the area has been hampered by the heterogeneity of mast cell responses and a lack of highly specific receptor agonists and antagonists. The expression of different adenosine receptor subtypes on mast cells is described. The final section of the review presents data to suggest that BAL mast cells may provide an accurate and relevant model for future investigations and together with the development of superior pharmacological tools, may aid the realisation of the therapeutic potential of adenosine/mast cell interactions in asthma. In conclusion, the role of adenosine in asthma is clearly complex. A better understanding of the contribution of adenosine to the asthmatic condition may lead to novel therapeutic approaches in the treatment of the disease.
引用
收藏
页码:301 / 307
页数:7
相关论文
共 70 条
[41]  
MARQUARDT DL, 1994, J IMMUNOL, V152, P4508
[42]  
MARQUARDT DL, 1978, J IMMUNOL, V120, P871
[43]  
MARQUARDT DL, 1989, J IMMUNOL, V142, P1268
[44]   MODULATION OF MAST-CELL RESPONSES TO ADENOSINE BY AGENTS THAT ALTER PROTEIN KINASE-C ACTIVITY [J].
MARQUARDT, DL ;
WALKER, LL .
BIOCHEMICAL PHARMACOLOGY, 1990, 39 (12) :1929-1934
[45]  
MARQUARDT DL, 1984, J IMMUNOL, V133, P932
[46]   ADENOSINE RELEASE FROM STIMULATED MAST-CELLS [J].
MARQUARDT, DL ;
GRUBER, HE ;
WASSERMAN, SI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (19) :6192-6196
[47]  
Meade CJ, 1996, J PHARMACOL EXP THER, V279, P1148
[48]  
MENTZER RM, 1975, AM J PHYSIOL, V229, P1625
[49]  
MOLLER A, 1993, J IMMUNOL, V151, P3261
[50]   BRONCHIAL BIOPSY EVIDENCE FOR LEUKOCYTE INFILTRATION AND UP-REGULATION OF LEUKOCYTE-ENDOTHELIAL CELL-ADHESION MOLECULES 6 HOURS AFTER LOCAL ALLERGEN CHALLENGE OF SENSITIZED ASTHMATIC AIRWAYS [J].
MONTEFORT, S ;
GRATZIOU, C ;
GOULDING, D ;
POLOSA, R ;
HASKARD, DO ;
HOWARTH, PH ;
HOLGATE, ST ;
CARROLL, MP .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) :1411-1421