The behaviors of human mesenchymal stem cells on the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) membranes

被引：18

作者：

Yu, Bo-Yi ^{[1
,2
]}

Chen, Po-Ya ^{[1
]}

Sun, Yi-Ming ^{[1
,3
,4
]}

Lee, Yu-Tsang ^{[2
,5
]}

Young, Tai-Horng ^{[2
]}

机构：

[1] Yuan Ze Univ, Dept Chem Engn & Mat Sci, Chung Li Taoyuan 320, Taiwan

[2] Natl Taiwan Univ, Inst Med Engn, Chungli 100, Taiwan

[3] Yuan Ze Univ, Grad Sch Biotechnol & Bioengn, Chung Li Taoyuan 320, Taiwan

[4] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Chungli 320, Taoyuan, Taiwan

[5] Min Sheng Gen Hosp, Dept Orthoped Surg, Tao Yuan 330, Taiwan

来源：

DESALINATION | 2008年 / 234卷 / 1-3期

关键词：

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) Human mesenchymal stem cells (hMSCs); Electrospun membrane; Cast membrane;

D O I：

10.1016/j.desal.2007.09.087

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a potential material for tissue engineering applications because of its excellent biodegradable and biocompatible properties. The aim of this study is to present a close picture of the interaction between human mesenchymal stein cells (hMSCs) and the surface characteristics of PHBHHx membranes. The surface characteristics of PHBHHx membranes were created by using compression-molding, solvent-casting, and electrospinning methods. The behaviors of the hMSCs performed differently on those membranes. The highly porous electrospun PHBHHx membranes are better substrates for culturing hMSCs as they can keep higher cell viability than the compression-molded PHBHHx membranes. Aggregation and cluster fort-nation of hMSCs were found only on the cast PHBHHx membranes.

引用

页码：204 / 211

页数：8

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