A Fas agonist induces high levels of apoptosis in haematological malignancies

被引：35

作者：

Greaney, P

Nahimana, A

Lagopoulos, L

Etter, AL

Aubry, D

Attinger, A

Beltraminelli, N

Huni, B

Bassi, I

Sordat, B

Demotz, S

Dupuis, M

Duchosal, MA

机构：

[1] Univ Lausanne Hosp, CHU Vaudois, Serv Hematol, CH-1011 Lausanne, Switzerland

[2] Apoxis SA, CH-1004 Lausanne, Switzerland

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 04期

关键词：

apoptosis; cytotoxicity; Fas; haematological malignancies; cancer;

D O I：

10.1016/j.leukres.2005.08.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We developed and tested a potent hexameric Fas agonist, termed MegaFasL, for its cytotoxic effects on a panel of human haematopoietic malignant cells and healthy human haematopoietic progenitor cells (CD34+CD38low). Results demonstrated that MegaFasL induced apoptosis in cell lines and primary cells representing multiple myeloma (MM), acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) and Burkitt's lymphoma. Cells from a chronic myeloid leukaemia (CML) line and from patients with chronic lymphocytic leukaemia (CLL) were resistant. Furthermore, CD34+CD38low progenitor cells were also resistant to MegaFasL. The data indicate that MegaFasL could be a highly efficient therapeutic agent ex vivo or potentially in vivo. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：415 / 426

页数：12

共 49 条

[11] Assay of human stem cells by repopulation of NOD/SCID mice
Dick, JE
Bhatia, M
Gan, O
Kapp, U
Wang, JCY
[J]. STEM CELLS, 1997, 15 : 199 - 203
[12] Dive C, 1992, Semin Cancer Biol, V3, P417
[13] Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
Dutton, A
O'Neil, JD
Milner, AE
Reynolds, GM
Starczynski, J
Crocker, J
Young, LS
Murray, PG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) : 6611 - 6616
[14] Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
El-Deiry, WS
[J]. CELL DEATH AND DIFFERENTIATION, 2001, 8 (11) : 1066 - 1075
[15] Monoclonal plasma cells in the blood stem cell harvest from patients with multiple myeloma are associated with shortened relapse-free survival after transplantation
Gertz, MA
Witzig, TE
Pineda, AA
Greipp, PR
Kyle, RA
Litzow, MR
[J]. BONE MARROW TRANSPLANTATION, 1997, 19 (04) : 337 - 342
[16] Gutiérrez MI, 1999, CANCER RES, V59, P696
[17] Apoptosis and the dilemma of cancer chemotherapy
Hannun, YA
[J]. BLOOD, 1997, 89 (06) : 1845 - 1853
[18] Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex
Holler, N
Tardivel, A
Kovacsovics-Bankowski, M
Hertig, S
Gaide, O
Martinon, F
Tinel, A
Deperthes, D
Calderara, S
Schulthess, T
Engel, J
Schneider, P
Tschopp, E
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (04) : 1428 - 1440
[19] Functional expression of Fas (CD95) in acute myeloid leukemia cells in the context of CD34 and CD38 expression: Possible correlation with sensitivity to chemotherapy
Iijima, N
Miyamura, K
Itou, T
Tanimoto, M
Sobue, R
Saito, H
[J]. BLOOD, 1997, 90 (12) : 4901 - 4909
[20] Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
Juo, P
Kuo, CJ
Yuan, JY
Blenis, J
[J]. CURRENT BIOLOGY, 1998, 8 (18) : 1001 - 1008

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