Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2

被引：52

作者：

Groth, C ^{[1
]}

Nornes, S ^{[1
]}

McCarty, R ^{[1
]}

Tamme, R ^{[1
]}

Lardelli, M ^{[1
]}

机构：

[1] Univ Adelaide, Dept Mol Biosci, Adelaide, SA 5005, Australia

来源：

DEVELOPMENT GENES AND EVOLUTION | 2002年 / 212卷 / 10期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Alzheimer's disease; presenilin; neural crest; melanocyte; zebrafish;

D O I：

10.1007/s00427-002-0269-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.

引用

页码：486 / 490

页数：5

共 26 条

[1] The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons [J].

Berezovska, O ;

Frosch, M ;

McLean, P ;

Knowles, R ;

Koo, E ;

Kang, D ;

Shen, J ;

Lu, FM ;

Lux, SE ;

Tonegawa, S ;

Hyman, BT .

MOLECULAR BRAIN RESEARCH, 1999, 69 (02) :273-280

[2] Presenilins, processing of β-amyloid precursor protein, and Notch signaling [J].

Chan, YM ;

Jan, YN .

NEURON, 1999, 23 (02) :201-204

[3] Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins [J].

DeStrooper, B ;

Beullens, M ;

Contreras, B ;

Levesque, L ;

Craessaerts, K ;

Cordell, B ;

Moechars, D ;

Bollen, M ;

Fraser, P ;

StGeorgeHyslop, P ;

VanLeuven, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3590-3598

[4] Mice lacking both presenilin genes exhibit early embryonic patterning defects [J].

Donoviel, DB ;

Hadjantonakis, AK ;

Ikeda, M ;

Zheng, H ;

Hyslop, PS ;

Bernstein, A .

GENES & DEVELOPMENT, 1999, 13 (21) :2801-2810

[5]

Felsenstein J., 1989, CLADISTICS, V5, P164, DOI DOI 10.1111/J.1096-0031.1989.TB00562.X

[6] Presenilin structure, function and role in Alzheimer disease [J].

Fraser, PE ;

Yang, DS ;

Yu, G ;

Lévesque, L ;

Nishimura, M ;

Arawaka, S ;

Serpell, LC ;

Rogaeva, E ;

St George-Hyslop, P .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2000, 1502 (01) :1-15

[7] LIN-12/Notch signaling: lessons from worms and flies [J].

Greenwald, I .

GENES & DEVELOPMENT, 1998, 12 (12) :1751-1762

[8]

Handler M, 2000, DEVELOPMENT, V127, P2593

[9] The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on Aβ42 amyloid peptide formation [J].

Jacobsen, H ;

Reinhardt, D ;

Brockhaus, M ;

Bur, D ;

Kocyba, C ;

Kurt, H ;

Grim, MG ;

Baumeister, R ;

Loetscher, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) :35233-35239

[10]

JOWETT T, 1997, TISSUE IN SITU HYBRI

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