Fibril formation in collagen

被引：36

作者：

Goh, MC

Paige, MF

Gale, MA

Yadegari, I

Edirisinghe, M

Strzelczyk, J

机构：

[1] Department of Chemistry, University of Toronto, Toronto

来源：

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | 1997年 / 239卷 / 1-3期

关键词：

D O I：

10.1016/S0378-4371(96)00472-4

中图分类号：

O4 [物理学];

学科分类号：

0702 [物理学];

摘要：

While simple aggregation in solution typically leads to ramified objects, some polymers and proteins form filamentous structures. The aggregation of collagen, a structural protein, from monomers to fibrils was studied by light scattering and atomic force microscopy. The presence of clear, stable intermediates indicates that the assembly proceeds in a modular or hierarchical fashion. Temperature and concentration dependence studies show that the detailed assembly mechanism may change under different conditions.

引用

收藏

页码：95 / 102

页数：8

相关论文

共 17 条

[1]

Darnell J., 1990, Molecular Cell Biology, V2nd ed.

[2]

AGGREGATION OF GLOBULAR-PROTEINS [J].

DEYOUNG, LR ;

FINK, AL ;

DILL, KA .

ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (12) :614-620

[3]

PHYSICAL ASPECTS OF THE GROWTH AND REGULATION OF MICROTUBULE STRUCTURES [J].

DOGTEROM, M ;

LEIBLER, S .

PHYSICAL REVIEW LETTERS, 1993, 70 (09) :1347-1350

[4]

DYNAMIC LIGHT-SCATTERING FROM COLLAGEN SOLUTIONS .1. TRANSLATIONAL DIFFUSION-COEFFICIENT AND AGGREGATION EFFECTS [J].

FLETCHER, GC .

BIOPOLYMERS, 1976, 15 (11) :2201-2217

[5]

PHASE-DIAGRAM OF MICROTUBULES [J].

FYGENSON, DK ;

BRAUN, E ;

LIBCHABER, A .

PHYSICAL REVIEW E, 1994, 50 (02) :1579-1588

[6]

SEQUENTIAL ASSEMBLY OF COLLAGEN REVEALED BY ATOMIC-FORCE MICROSCOPY [J].

GALE, M ;

POLLANEN, MS ;

MARKIEWICZ, P ;

GOH, MC .

BIOPHYSICAL JOURNAL, 1995, 68 (05) :2124-2128

[7]

THE ROD DOMAIN OF NF-L DETERMINES NEUROFILAMENT ARCHITECTURE, WHEREAS THE END DOMAINS SPECIFY FILAMENT ASSEMBLY AND NETWORK FORMATION [J].

HEINS, S ;

WONG, PC ;

MULLER, S ;

GOLDIE, K ;

CLEVELAND, DW ;

AEBI, U .

JOURNAL OF CELL BIOLOGY, 1993, 123 (06) :1517-1533

[8]

RECONSTITUTION OF COLLAGEN FIBRILS INVITRO - THE ASSEMBLY PROCESS DEPENDS ON THE INITIATING PROCEDURE [J].

HOLMES, DF ;

CAPALDI, MJ ;

CHAPMAN, JA .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1986, 8 (03) :161-166

[9]

ATOMIC-FORCE MICROSCOPY PROBE TIP VISUALIZATION AND IMPROVEMENT OF IMAGES USING A SIMPLE DECONVOLUTION PROCEDURE [J].

MARKIEWICZ, P ;

GOH, MC .

LANGMUIR, 1994, 10 (01) :5-7

[10]

MCINTOSH JR, 1989, SCIENCE, V246, P622